Autonomous Microlasers for Profiling Extracellular Vesicles from Cancer Spheroids

Wang, Ziyihui; Fang, Guocheng; Gao, Zehang; Liao, Yikai; Gong, Chen; Kim, Munho; Chang, Guo‐En; Feng, Shilun; Xu, Tianhua; Liu, Tiegen; Chen, Yu Cheng

doi:10.1021/acs.nanolett.2c04123

Cited by 7 publications

(1 citation statement)

References 62 publications

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“…Medical diagnostics. Liquid crystal biosensors enable the rapid and sensitive detection of specific biomolecules or pathogens in clinical samples, aiding in the diagnosis of diseases [5]. These biosensors have been employed in the detection of various analytes (e.g., proteins, DNA, RNA and viruses), leading to early disease progression and improved patient outcomes.…”

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confidence: 99%

Optical Biosensing of Polarized Light

Kudreyko,

Chigrinov

2023

Crystals

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Interactions between liquid crystal molecules and target analytes open up various biosensing applications for quick screening and point-of-care applications. In this review, we categorized biosensors by type, depending on the liquid crystal mesophase, and considered several applications for the detection of biomolecules, point-of-care diagnostics and environmental monitoring. We also discuss interactions between polarized light and target pathogens dispersed in biological fluids, which result in the change of the polarization state. An array of the Stokes parameters can be compared with the pattern, and a proper pathogen can be manifested. We suggest that a combination of a micropolarizer array and a complementary metal oxide semiconductor sensor is an optimal setup for the detection of pathogens. Herein, we discuss the working principles of liquid crystal biosensors and their fabrication principles. In addition, relevant theoretical and practical issues related to liquid crystal biosensors are outlined. In general, this review gives an in-depth survey of the research on liquid crystal-based sensors, making it easier for researchers to locate their niche and make contributions to this subject from multiple viewpoints.

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confidence: 99%

Optical Biosensing of Polarized Light

Kudreyko,

Chigrinov

2023

Crystals

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Untethered Micro/Nanorobots for Remote Sensing: Toward Intelligent Platform

Wang,

Yang,

Zhang

2023

Nano-Micro Lett.

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Untethered micro/nanorobots that can wirelessly control their motion and deformation state have gained enormous interest in remote sensing applications due to their unique motion characteristics in various media and diverse functionalities. Researchers are developing micro/nanorobots as innovative tools to improve sensing performance and miniaturize sensing systems, enabling in situ detection of substances that traditional sensing methods struggle to achieve. Over the past decade of development, significant research progress has been made in designing sensing strategies based on micro/nanorobots, employing various coordinated control and sensing approaches. This review summarizes the latest developments on micro/nanorobots for remote sensing applications by utilizing the self-generated signals of the robots, robot behavior, microrobotic manipulation, and robot-environment interactions. Providing recent studies and relevant applications in remote sensing, we also discuss the challenges and future perspectives facing micro/nanorobots-based intelligent sensing platforms to achieve sensing in complex environments, translating lab research achievements into widespread real applications.

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An mCherry biolaser based on microbubble cavity with ultra-low threshold

Ma,

Zhao,

Peng

et al. 2023

Applied Physics Letters

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Biolasers show considerable potential in the biomedical field. Fluorescent protein (FP) is a type of biomaterial with good luminescence efficiency that can be used as the luminescent gain medium in biolasers. Due to the higher cell/tissue permeability, lower cell phototoxicity, and relatively less background fluorescence than other fluorescent proteins, the red fluorescent protein is more suitable in biological applications. MCherry is the most extensively used high-quality red fluorescent protein because of its short maturation time and stable luminescence properties. In this study, using mCherry and microbubble cavity, we realize a highly stable mCherry fluorescent protein laser. The laser resonator achieves a quality factor of 108, which is the highest Q factor among the currently available FP lasers. Moreover, this laser exhibits a low threshold of 1.15 μJ/mm2, which can effectively protect the luminescent material from being damaged by pump light. The prepared laser shows excellent stability in a wide pH range with good photobleaching resistance and can be stored at 4 °C for 30 days. Also, the laser can serve as a high-sensitivity molecular concentration detector with mCherry as biomarker, owing to its lasing threshold behavior.

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Autonomous Microlasers for Profiling Extracellular Vesicles from Cancer Spheroids

Cited by 7 publications

References 62 publications

Optical Biosensing of Polarized Light

Optical Biosensing of Polarized Light

Untethered Micro/Nanorobots for Remote Sensing: Toward Intelligent Platform

An mCherry biolaser based on microbubble cavity with ultra-low threshold

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