Masonry has superior fire resistance properties stemming from its inert characteristics, and slow degradation of mechanical properties. However, once exposed to fire conditions, masonry undergoes a series of physio-chemical changes. Such changes are often described via temperature-dependent material models. Despite calls for standardization of such models, there is a lack in such standardized models. As a result, available temperature-dependent material models vary across various fire codes and standards. In order to bridge this knowledge gap, this paper presents three methodologies, namely, regression-based, probabilistic-based, and the use of artificial neural (ANN) networks, to derive generalized temperature-dependent material models for masonry with a case study on the compressive strength property. Findings from this paper can be adopted to establish updated temperature-dependent material models of fire design and analysis of masonry structures.