Autonomous Cortisol Secretion by a Lipoid Cell Tumor of the Ovary

Rj, Chetkowski; Hl, Judd; Pi, Jagger; Rk, Nieberg; Rj, Chang

doi:10.1001/jama.1985.03360180132042

Cited by 17 publications

(4 citation statements)

References 9 publications

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“… 2 Moreover, about 6%‐10% of these patients were determined to present Cushing's syndrome due to excess cortisol production. 2 , 7 …”

Section: Discussion/conclusionmentioning

confidence: 99%

“… 3,6 Hyperestrogenism was also reported in 6% to 23% of cases, giving rise to symptoms such as menorrhagia, postmenopausal bleeding, and even endometrial carcinoma. 2 Moreover, about 6%‐10% of these patients were determined to present Cushing's syndrome due to excess cortisol production 2,7 …”

Section: Discussion/conclusionmentioning

confidence: 99%

“…2 Moreover, about 6%-10% of these patients were determined to present Cushing's syndrome due to excess cortisol production. 2,7 The majority of the steroid cell tumor appears solid or mostly solid on imaging. Calcification is not commonly seen within the tumor and is usually not associated with ascites.…”

Section: Discussion/conclusionmentioning

confidence: 99%

See 2 more Smart Citations

Recurrent ovarian steroid cell tumour not otherwise specified: A case report

Baharudin

Mohammad

Abdullah

et al. 2021

Clinical Case Reports

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“… 2 Moreover, about 6%‐10% of these patients were determined to present Cushing's syndrome due to excess cortisol production. 2 , 7 …”

Section: Discussion/conclusionmentioning

confidence: 99%

Section: Discussion/conclusionmentioning

confidence: 99%

See 1 more Smart Citation

Recurrent ovarian steroid cell tumour not otherwise specified: A case report

Baharudin

Mohammad

Abdullah

et al. 2021

Clinical Case Reports

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“…This excess of estrogen can result in menorrhagia or postmenopausal bleeding and ultimately endometrial adenocarcinoma [ 2 ]. There are reports of cortisol release by these tumors, and these can present in a clinical picture similar to Cushing's syndrome [ 3 , 4 ]. Approximately 25% of steroid cell tumors NOS do not produce any hormones.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Malignant Ovarian Steroid Cell Tumor: A Case Report and Review of the Literature

Lee

John

Liang

et al. 2016

Case Reports in Obstetrics and Gynecology

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We report a case of malignant ovarian steroid cell tumor not otherwise specified (NOS) in a 47-year-old female who presented with hirsutism, virilization, and amenorrhea. At the time of laparotomy, the tumor had already spread to the pelvic cul-de-sac. She underwent a total hysterectomy, bilateral salpingo-oophorectomy, and tumor resection with no residual disease. She received three cycles of bleomycin, etoposide, and cisplatin (BEP) and is now free of disease 24 months after surgery. Literature review of ovarian steroid cell tumors NOS including clinicopathological features and clinical management was performed.

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Aberrant hormone production from ovarian neoplasms: Strategies for diagnosis and therapy

et al. 1990

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Syndromes involving peptide or nonsex steroid hormone secretion due to aberrantly located tumors are rare. We report a collected series of 16 patients with ectopic hormone production from ovarian neoplasms, including 3 patients recently encountered at our institution as well as 13 additional cases identified in the recent literature. These tumors included 2 insulin-producing ovarian carcinoids, 1 ACTH-producing pituitary adenoma within a benign ovarian cystic teratoma, 2 cortisol-producing ovarian neoplasms, 8 gastrin-producing ovarian cystadenomata or cystadenocarcinomata, and 3 thyroxine-producing ovarian strumal carcinoids. All patients presented with syndromes of hormone excess. Only 62% of all tumors were localized preoperatively. Following ovarian resection, 87% of patients remained disease-free with a median follow-up period of 1.5 years. In addition to ovariectomy, 8 additional unnecessary ablative procedures were performed in 7 patients. These included distal pancreatectomy, pancreaticoduodenectomy, adrenalectomy, total gastrectomy, selective vagotomy, and subtotal thyroidectomy. Failure to localize the ovarian neoplasm preoperatively was associated with a significantly higher risk of subsequent unnecessary ablative procedures. Because of the potential for the ovary to act as a source of aberrant hormone secretion, we recommend complete preoperative evaluation of the pelvis in female patients presenting with nonlocalizable endocrine tumors.

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Autonomous Cortisol Secretion by a Lipoid Cell Tumor of the Ovary

Cited by 17 publications

References 9 publications

Recurrent ovarian steroid cell tumour not otherwise specified: A case report

Recurrent ovarian steroid cell tumour not otherwise specified: A case report

Metastatic Malignant Ovarian Steroid Cell Tumor: A Case Report and Review of the Literature

Aberrant hormone production from ovarian neoplasms: Strategies for diagnosis and therapy

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