Recurrent ovarian steroid cell tumour not otherwise specified: A case report

Baharudin, Azmaniza; Mohammad, M. S. Dewan Muthu; Abdullah, Munirah; Aliyas, Ismail; Noor, Mohd Rushdan Mohd; Yazid, Mohd Nazri; Yuan, Victor Chin Jian; Jamil, Amilia Afzan Mohd

doi:10.1002/ccr3.4414

Cited by 2 publications

(4 citation statements)

References 21 publications

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“…According to previous studies, serum estrogen levels are low in postmenopausal women with CKD treated with hemodialysis [ 7 ]. Such hormonal imbalance in patients with CKD causes bleeding in the endometrium, but there may also be an imbalance due to hormones secreted by tumors [ 2 ]. This patient had an incidental ovarian steroid cell tumor that produced hormones.…”

Section: Discussionmentioning

confidence: 99%

“…Precocious puberty can also occur in children. In adults, virilizing signs such as hoarseness of voice, hirsutism, and amenorrhea have been reported [ 2 ]. In this case, signs of virilization including acne, hirsutism, and male pattern alopecia were not identified.…”

Section: Discussionmentioning

confidence: 99%

“…In postmenopausal women, hematometra is commonly associated with cervical stenosis due to senile atrophy, radiotherapy, or neoplastic lesions involving the uterus [ 1 ]. Ovarian steroid cell tumors are a rare subtype of hormone-secreting tumors that account for approximately 0.1% of all ovarian tumors [ 2 ]. Here, we report a case of hematometra in a postmenopausal woman with high estrogen levels who was later confirmed to have a steroid cell tumor.…”

Section: Introductionmentioning

confidence: 99%

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Hematometra Due to Cervical Stenosis in a Postmenopausal Woman with Incidental Ovarian Steroid Cell Tumor: A Case Report

2022

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Vaginal bleeding is reported among 4%–11% of postmenopausal women. Hematometra is commonly associated with cervical stenosis due to senile atrophy, radiotherapy, or a uterine neoplastic lesion in women of postmenopausal age. Ovarian steroid cell tumor is a rare hormone-secreting tumor subtype accounting for approximately 0.1% of all ovarian tumors. Here we report a case of hematometra in a postmenopausal woman with high estrogen levels who was later diagnosed with a steroid cell tumor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hematometra Due to Cervical Stenosis in a Postmenopausal Woman with Incidental Ovarian Steroid Cell Tumor: A Case Report

2022

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“…Subsequently, four courses of bleomycin+etoposide+cisplatin (BEP), followed by six courses of etoposide+cisplatin (EP), were administered 19…”

Section: Treatmentmentioning

confidence: 99%

Somatic gene mutations in malignant steroid cell tumours and response to multiple treatments

Nakanishi

Fukagawa²,

Yamada³

et al. 2022

BMJ Case Rep

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Malignant ovarian steroid cell tumours are a rare subgroup of sex cord-stromal tumours. There are no systematic reviews on the associated treatments, and little is known about their genomic profile. We describe a case of a pelvic malignant ovarian steroid cell tumour in a premenopausal woman in her 40s. She received cytoreductive surgery and six cycles of paclitaxel+carboplatin+bevacizumab. After recurrence, the tumour was surgically removed again, followed by radiation and hormone blockade therapy. Complete remission was achieved after treatment with bleomycin, etoposide and cisplatin. She remained in a platinum-sensitive relapse state and subsequently received maintenance therapy with olaparib. Since the tumour was initially refractory to treatment, tissue specimens were screened for gene mutations using a next-generation sequencing oncology panel and a somatic variant detection system, which revealed somatic gene mutations in ARID1A, PIK3CA, TERT and ATM, some of which are involved in DNA repair.

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Recurrent ovarian steroid cell tumour not otherwise specified: A case report

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 2 publications

References 21 publications

Hematometra Due to Cervical Stenosis in a Postmenopausal Woman with Incidental Ovarian Steroid Cell Tumor: A Case Report

Hematometra Due to Cervical Stenosis in a Postmenopausal Woman with Incidental Ovarian Steroid Cell Tumor: A Case Report

Somatic gene mutations in malignant steroid cell tumours and response to multiple treatments

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