Autonomic responses and neural-cardiac coupling during individually tailored symptom provocation in obsessive-compulsive disorder

Neural correlates of symptom provocation in pediatric obsessive-compulsive disorder

“…This is notable, as a recent review of behavioural studies using OCD or subclinical OCD participants (de Putter et al., 2017) did not identify any studies examining the provocation with the symmetry subdimension. Additionally, although previous OCD imaging studies have included Just Right dimension stimuli (Adler et al., 2000; Banca et al., 2015; de Wit et al., 2015; Simon et al., 2014, 2013, 2010) they often focus on the counting, ordering or symmetry subdimensions, and miss the repeating subdimension. Given that Just Right symptoms may predict treatment response (Højgaard et al., 2018), all of the subdimensions of the Just Right factor deserve further exploration.…”

Meta-analytic review of the effects of a single dose of intranasal oxytocin on threat processing in humans

“…Behavioural studies have demonstrated that people with PTSD, OCD, and ED show anomalies in physiological response to threat. For example, there is an exaggerated physiological startle response to anticipation and viewing of disorder-specific, potentially threatening stimuli, such as images of trauma, contamination, or food (Altman et al, 2013;Mauler et al, 2006;Pitman et al, 2012;Simon et al, 2013). Additionally, a number of reviews have reported atypical attentional bias towards disorder specific stimuli (Bar-Haim et al, 2007;Brooks et al, 2011;Cisler and Koster, 2010).…”

Association between Obsessive-Compulsive Symptoms and Long-Term Cardiac Outcomes in Patients with Acute Coronary Syndrome: Effects of Depression Comorbidity and Treatment

“…Second, patients with OCD have persistent anxiety and therefore have an exhausted autonomic nervous system [28]. In a functional brain magnetic resonance imaging study, activities increased in the limbic and paralimbic areas, indicating that the dorsolateral prefrontal cortex was hyperactivated in OCD patients [29]. A meta-analysis reported that OCD results in less total sleep time and a higher amount of awake time than in people without OCD.…”