Autonomic Regulation of Glucose Homeostasis: a Specific Role for Sympathetic Nervous System Activation

Carnagarin, Revathy; Matthews, Vance B.; Herat, Lakshini Y.; Ho, Jan K.; Schlaich, Markus P.

doi:10.1007/s11892-018-1069-2

Cited by 39 publications

(24 citation statements)

References 105 publications

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“…In addition, the association between hyperglycemia and autonomic dysfunction may be bidirectional. It has been suggested that autonomic dysfunction causes hyperglycemia via impaired insulin release by the pancreas, increased glucose production by the liver, and impaired glucose uptake and insulin resistance in skeletal muscles (32). Indeed, several studies have shown that cardiac autonomic dysfunction measured by high heart rate or low HRV is associated with incident type 2 diabetes (33,34).…”

Section: Discussionmentioning

confidence: 99%

Both Prediabetes and Type 2 Diabetes Are Associated With Lower Heart Rate Variability: The Maastricht Study

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Both Prediabetes and Type 2 Diabetes Are Associated With Lower Heart Rate Variability: The Maastricht Study

et al. 2020

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“…Additionally, results showed that 12-month of chronic cervical VNS significantly increased body weight of patients with drug-resistant epilepsy without obviously affecting their systolic and diastolic blood pressure. The autonomic nervous system (ANS), which composed of sympathetic and parasympathetic (vagal) branches is crucial in regulating glucose metabolism [17][18][19][20] . Furthermore, the central nervous system (CNS) maintains glucose homeostasis through ANS mediated control of the metabolically relevant organs including pancreas, liver, gut, skeletal muscle, and brown and white adipose tissues [21,22] .…”

Section: Discussionmentioning

confidence: 99%

Chronic vagus nerve stimulation for drug-resistant epilepsy may influence fasting blood glucose concentration

Liu

Zhan

Meng

et al. 2020

Preprint

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Background Cervical vagus nerve stimulation (VNS) has been widely accepted as adjunctive therapy for drug-resistant epilepsy and major depression. Its effects on glycemic control in humans were however poorly understood. The aim of our study was to investigate the potential effects of VNS on fasting blood glucose (FBG) in patients with drug-resistant epilepsy. Methods Patients with drug-resistant epilepsy who had received VNS implants at the same hospital were retrospectively studied. Effects on FBG, weight, body mass index and blood pressure were evaluated at 4, 8 and 12 months of follow-up. Results 32 subjects (11 females/21males, 19±9 years, body mass index 22.2±4.0 kg/m 2 ) completed 12-month follow-up. At the 4 months, there were no significant changes in FBG concentrations from baseline to follow-up in both Sham-VNS (4.89±0.54 vs. 4.56±0.54 mmol/L, N=13, p=0.101) and VNS (4.80±0.54 vs. 4.50±0.56 mmol/L, N=19, p=0.117) groups. However, after 8 (4.90±0.42 mmol/L, N=32, p=0.001) and 12 (4.86±0.40 mmol/L, N=32, p=0.002) months of VNS, FBG levels significantly increased compared to baseline values (4.52±0.54 mmol/L, N=32). Changes in FBG concentrations at both 8 (R 2 =0.502, N=32, p<0.001) and 12 (R 2 =0.572, N=32, p<0.001) months were negatively correlated with baseline FBG levels. Conclusions Our study suggests that chronic cervical VNS elevates FBG levels with commonly used stimulation parameters in patients with epilepsy.

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“…In addition, results showed that 12-month chronic cervical VNS significantly increased body weight of patients with drug-resistant epilepsy without obviously affecting their systolic and diastolic blood pressure. The autonomic nervous system (ANS), which composed of sympathetic and parasympathetic (vagal) branches, is crucial in regulating glucose metabolism [15][16][17][18]. Furthermore, the central nervous system (CNS) maintains glucose homeostasis through ANS-mediated control of the metabolically relevant organs including pancreas, liver, gut, skeletal muscle, and brown and white adipose tissues [19,20].…”

Section: Discussionmentioning

confidence: 99%

Chronic vagus nerve stimulation for drug-resistant epilepsy may influence fasting blood glucose concentration

et al. 2020

View full text Add to dashboard Cite

show abstract

Autonomic Regulation of Glucose Homeostasis: a Specific Role for Sympathetic Nervous System Activation

Cited by 39 publications

References 105 publications

Both Prediabetes and Type 2 Diabetes Are Associated With Lower Heart Rate Variability: The Maastricht Study

Both Prediabetes and Type 2 Diabetes Are Associated With Lower Heart Rate Variability: The Maastricht Study

Chronic vagus nerve stimulation for drug-resistant epilepsy may influence fasting blood glucose concentration

Chronic vagus nerve stimulation for drug-resistant epilepsy may influence fasting blood glucose concentration

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