Both Prediabetes and Type 2 Diabetes Are Associated With Lower Heart Rate Variability: The Maastricht Study

Abstract

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Long-term prognostic utility of low-density lipoprotein (LDL) triglyceride in real-world patients with coronary artery disease and diabetes or prediabetes

“…Interestingly, although Pre-DM individuals present modestly raised glucose levels, similar cardiac abnormalities of DM subjects were also observed in these patients. For example, Coopmans et al has reported that Pre-DM and DM are similarly associated with reduction of heart rate variability [17]. Previous studies including ours have also indicated that patients with DM or Pre-DM have similar pro-atherogenic lipid profiles [12].…”

Early changes in ambulatory electrocardiography after transcatheter closure in patients with atrial septal defect and factors affecting heart rate variability

“…This may mean that transcatheter closure could reduce the risk of cardiac death in patients with ASD and improve prognosis. Moreover, patients with diabetes or prediabetes have lower HRV [25,26]. Diabetes-related cardiac autonomic dysfunction plays an important role in the decrease in HRV [27].…”

Chronic Microvascular Complications in Prediabetic States—An Overview

“…A number of studies have concerned the association between autonomic disfunction and prediabetes [ 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ] ( Table 3 ). A great diversity of results was observed in these studies when it comes to the discussed glucose metabolism disorders, the size of the groups undergoing research, and cardiovascular autonomic neuropathy (CAN) testing methods.…”

“…Nine studies followed IGT defined according to the WHO 1999 guidelines with 2-h post-load glucose levels between 140 and 199 mg/dL (7.8–11.0 mmol/L) in OGTT [ 78 , 81 , 84 , 85 , 86 , 87 , 88 , 89 ]. One study took into consideration an IFG-IGT group (defined according to ADA 2003 and WHO 1999 guidelines) [ 87 ], while two studies did not differentiate between these prediabetic states [ 90 , 91 ]. Seven studies included a small group (below 200 participants) [ 76 , 77 , 81 , 84 , 86 , 88 , 90 ], and six studies encompassed more than 1000 participants [ 76 , 79 , 80 , 82 , 83 , 91 ].…”

“…One study took into consideration an IFG-IGT group (defined according to ADA 2003 and WHO 1999 guidelines) [ 87 ], while two studies did not differentiate between these prediabetic states [ 90 , 91 ]. Seven studies included a small group (below 200 participants) [ 76 , 77 , 81 , 84 , 86 , 88 , 90 ], and six studies encompassed more than 1000 participants [ 76 , 79 , 80 , 82 , 83 , 91 ]. The size of groups undergoing research ranged from 80 to 9940.…”