Autonomic nervous function in patients with Meniere’s disease evaluated by power spectral analysis of heart rate variability

Yamada, Masahiko; Mizuta, Keisuke; Ito, Yatsuji; Furuta, Michiya; Sawai, Shigeo; Miyata, Hideo

doi:10.1016/s0385-8146(99)00021-8

Cited by 13 publications

(12 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The theory that autonomic dysfunction plays a role in the pathophysiology of Meniere's disease has been considered in the literature 39–45 . In contrast with previous studies, this analysis does not present evidence supporting an autonomic etiology for Meniere's disease.…”

Section: Discussioncontrasting

confidence: 64%

Autonomic related vertigo

Pappas¹

2003

The Laryngoscope

View full text Add to dashboard Cite

Objectives:To demonstrate clinical evidence that vestibular symptomatology can occur in relation to autonomic dysfunction. Characterization of clinical findings and treatment response would then allow autonomic related vertigo to be differentiated from other vertiginous conditions that present in a like manner. Study Desigm This was a retrospective review of 113 patients that described symptoms consistent with spontaneous, rotational vertigo and autonomic dysfunction. Methods: Vestibular, otologic, and autonomic symptoms are presented along with the results of audiologic, orthostatic, and autonomic testing. Medical management included fluid loading, dietary changes, exercise, and patient education. Treatment results were analyzed according to the effectiveness in control of vestibular and otologic symptoms. Results were compared with a control group that demonstrated a similar vestibular and otologic presentation without autonomic symptomatology. Renults: All patients described spontaneous, rotational vertigo, with complete or substantial vertigo control obtained in 93 (85%) of 110 patients. Postural vertigo and distinct lightheadedness were also documented in 53% and 97% of cases, respectively. Vertigo failed to improve or worsened with prior treatment of low sodium diet or diuretic in 53 (91%) of 58 cases. Vertigo improvement was subsequently achieved in 48 (86%) of 56 cases with an autonomic treatment regimen. Long-term vertigo control was obtained in 56 (88%) of64 patients followed for at least 18 months. Tinnitus was reported in 97 (86%) patients, aural fullness in 93 (82%) patients, and subjective hearing loss (HL) Orthostatic blood pressure and heart rate testing met the criteria for orthostatic hypotension in 16 (16%) of 104 patients. Autonomic testing was obtained in 34 cases, with orthostatic intolerance demonstrated in 33 (97%) patients and orthostatic hypotension demonstrated in 13 (38%) patients. Overall, orthostatic hypotension was documented through combined testing results in 23 (21%) of 107 patients. Vertigo was reproduced during autonomic testing in 17 (77%) of 22 patients, and otologic symptoms were reproduce in 9 (47%) of 19 patients. Comparison of the study population with a control group without autonomic symptoms revealed statistically significant differences in orthostatic testing and treatment results. There was no statistical difference noted in findings between patients of this study that demonstrated or failed to demonstrate orthostatic hypotension. Conclusions: There is a subgroup of patients with spontaneous vertigo who also demonstrate symptoms and findings consistent with poor autonomic regulation. These patients report vertigo improvement with a treatment strategy that aims to improve autonomic dysfunction through expansion of effective circulating volume. Clinical findings and treatment results of this study suggest an underlying autonomic influence in the production of vertigo and otologic symptoms.

show abstract

Section: Discussioncontrasting

confidence: 64%

Autonomic related vertigo

Pappas¹

2003

The Laryngoscope

View full text Add to dashboard Cite

show abstract

“…Previous studies have reported significant parasympathetic nervous hypofunction in vertigo patients, which is similar to the findings of our study (Fig. B).…”

Section: Discussionsupporting

confidence: 93%

“…It was recorded for 2.5 min and the frequency domain information was analyzed automatically with a fast Fourier transform. The technical details of HRV analysis have been presented in detail previously . In brief, the power spectral components of the R–R interval between 0.04–0.15 Hz were considered LF components and those between 0.15–0.40 Hz were considered HF components.…”

Section: Methodsmentioning

confidence: 99%

“…Heart rate variability can reflect the dynamic interplay between ongoing perturbations in circulatory function and the compensatory responses of short‐term cardiovascular control systems. Analysis of HRV includes low‐frequency (LF) fluctuations, which reflect both parasympathetic and sympathetic activity, and high‐frequency (HF) fluctuations, which reflect parasympathetic activity. These findings have been used for the evaluation of ANA in vertigo patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative stress and heart rate variability in patients with vertigo

Ohara

Inoue

Sumi

et al. 2014

Acute Medicine & Surgery

View full text Add to dashboard Cite

Aims: Peripheral vertigo has been reported to result from oxidative stress or autonomic nervous dysfunction. Recently, heart rate variability has been used to evaluate autonomic nervous activity. Parasympathetic nervous dysfunction is associated with peripheral vertigo; however, the relationships between vertigo, oxidative stress, and autonomic nervous activity have not been investigated. The aim of this study was to elucidate the changes in oxidative stress and autonomic nervous activity in vertigo patients compared with healthy volunteers.Methods: Oxidative stress was assessed by evaluating biological antioxidant potential and reactive oxygen metabolites, and heart rate variability was measured to evaluate autonomic nervous activity. Thirty-four patients who complained of peripheral vertigo and were treated in our emergency department between January and August 2011 were enrolled in study 1. Oxidative stress and heart rate variability were measured and compared with those of healthy volunteers (n = 23). In study 2, oxidative stress in 18 vertigo patients and heart rate variability in 41 vertigo patients were measured between January and August 2012 before and after conventional treatment of vertigo to evaluate the effect of the treatment on oxidative stress and autonomic nervous activity.Results: Reactive oxygen metabolites were higher in vertigo patients than in healthy volunteers. Parasympathetic nervous activity was lower and the sympathetic/parasympathetic nervous activity ratio (autonomic nervous activity ratio) was higher in vertigo patients than in healthy volunteers. After treatment of vertigo, reactive oxygen metabolites decreased significantly and the autonomic nervous activity ratio became similar to that observed in healthy volunteers.Conclusions: Bedside monitoring of oxidative stress and heart rate variability may be useful for the diagnosis of vertigo and evaluation of the effect of treatment.

show abstract

“…Autonomic nervous dysfunction plays a role as a predisposing factor, a trigger or as a consequence of vertigo [ 17 ]. Recording the heart rate variability (HRV) is an easy, non-invasive method to investigate autonomic balance [ 18 , 19 ].…”

Section: Methodsmentioning

confidence: 99%

Efficacy and safety of acupuncture for dizziness and vertigo in emergency department: a pilot cohort study

Chiu

Lee

Hsu

et al. 2015

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundDizziness and vertigo account for roughly 4% of chief symptoms in the emergency department (ED). Pharmacological therapy is often applied for these symptoms, such as vestibular suppressants, anti-emetics and benzodiazepines. However, every medication is accompanied with unavoidable side-effects. There are several research articles providing evidence of acupuncture treating dizziness and vertigo but few studies of acupuncture as an emergent intervention in ED. We performed a pilot cohort study to evaluate the efficacy and safety of acupuncture in treating patients with dizziness and vertigo in ED.MethodsA total of 60 participants, recruited in ED, were divided into acupuncture and control group. Life-threatening conditions or central nervous system disorders were excluded to ensure participants’ safety. The clinical effect of treating dizziness and vertigo was evaluated by performing statistical analyses on data collected from questionnaires of Dizziness Handicap Inventory (DHI), Visual Analog Scale (VAS) of dizziness and vertigo, and heart rate variability (HRV).ResultsThe variation of VAS demonstrated a significant decrease (p-value: 0.001 and p-value: 0.037) between two groups after two different durations: 30 mins and 7 days. The variation of DHI showed no significant difference after 7 days. HRV revealed a significant increase in high frequency (HF) in the acupuncture group. No adverse event was reported in this study.ConclusionAcupuncture demonstrates a significant immediate effect in reducing discomforts and VAS of both dizziness and vertigo. This study provides clinical evidence on the efficacy and safety of acupuncture to treat dizziness and vertigo in the emergency department.Trial registrationClinicalTrials.gov ID: NCT02358239. Registered 5 February 2015

show abstract

Autonomic nervous function in patients with Meniere’s disease evaluated by power spectral analysis of heart rate variability

Cited by 13 publications

References 20 publications

Autonomic related vertigo

Autonomic related vertigo

Oxidative stress and heart rate variability in patients with vertigo

Efficacy and safety of acupuncture for dizziness and vertigo in emergency department: a pilot cohort study

Contact Info

Product

Resources

About