Autonomic Healing of Acrylic Bone Cement

Gladman, A. Sydney; Celestine, Asha‐Dee N.; Sottos, Nancy R.; White, Scott R.

doi:10.1002/adhm.201400084

Cited by 21 publications

(23 citation statements)

References 39 publications

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“…A good solvent is one for which the interactions between the polymer segments and solvent molecules are more energetically favorable than those between the polymer segments themselves and is usually identified as one whose solubility parameter (d) is close to that of the polymer [29,33]. Good solvents for PMMA include ethyl phenylacetate (EPA), phenylacetate (PA), chlorobenzene (PhCl) and anisole.…”

Section: Introductionmentioning

confidence: 99%

“…Good solvents for PMMA include ethyl phenylacetate (EPA), phenylacetate (PA), chlorobenzene (PhCl) and anisole. Gladman et al have recently demonstrated autonomous solvent healing in a bone cement thermoplastic system containing microcapsules with a liquid PMMA-anisole core material [33]. PMMA was added to the core solvent (anisole) to promote increased healing efficiency in small scale cracks within the bone cement system and to promote environmental stability of the microcapsules [33].…”

Section: Introductionmentioning

confidence: 99%

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Autonomic healing of PMMA via microencapsulated solvent

Celestine

Sottos

White

2015

Polymer

Self Cite

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Autonomic healing of PMMA via microencapsulated solvent

Celestine

Sottos

White

2015

Polymer

Self Cite

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“…Consequently, these systems need additional healing agents to enable self‐healing. The most common strategy toward design of extrinsic self‐healing biomaterials was pioneered by White and co‐workers and entails the incorporation of capsules containing healing liquids into a non‐self‐healing matrix ( Figure ). In these biomaterials, mechanical damage induces rupture of the capsules and release of their cargo into microcracks to enable self‐healing.…”

Section: Extrinsic Self‐healing Biomaterialsmentioning

confidence: 99%

“…As mentioned above, the surface of the glass particles is coated with a silane coupling agent such as 3‐(triethoxysilyl)propyl methacrylate to improve the mechanical properties of resin‐based dental composites by forming covalent bonds between the glass surface and the resin matrix. [15a,17,18]…”

Section: Extrinsic Self‐healing Biomaterialsmentioning

confidence: 99%

“…The matrix phase of bone cements is prepared by mixing a powder with a liquid phase. The powder phase consists of prepolymerized poly(methyl methacrylate) (PMMA) particles,[17,22a,c,23] barium sulfate as radiopacifier, and BPO as initiator. [10a] The liquid phase usually contains MMA as main component, N , N ‐dimethyl‐ p ‐toluidine as accelerator and hydroquinone as stabilizer to prevent premature polymerization.…”

Section: Extrinsic Self‐healing Biomaterialsmentioning

confidence: 99%

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Self‐Healing Biomaterials: From Molecular Concepts to Clinical Applications

Diba

Spaans

Ning

et al. 2018

Adv Materials Inter

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were selected "off-the-shelf" based on the ingenuity of the surgeons. [1] During the last century, significant medical and technological progress has paved the way for the field of biomaterials research and the emergence of a biomaterials industry. Various synthetic or natural biomaterials have been developed which have enabled treatment of a wide range of medical conditions. Nevertheless, biomaterials are being considered for increasingly complex indications, which has increased the requirements for biomaterials considerably during the past decades. [2] Consequently, challenging-or even contradictorycombinations of biomaterial properties are often required which cannot be met by conventional biomaterials. For instance, biomaterials are desired which combine injectability, mechanical strength, and degradability with toughness to avoid mechanical damage following crack propagation. To meet these strict requirements, biomaterials are needed which can adapt to the implantation site and are able to heal themselves upon mechanical damage. While the majority of synthetic biomaterials does not recover from mechanical damage, natural tissues display a remarkable capacity for self-healing such as the spontaneous self-repair of bone fractures or ruptured skin. This self-healing ability is the ultimate solution of nature for continued survival based Biomaterials are being applied in increasingly complex areas such as tissue engineering, bioprinting, and regenerative medicine. For these applications, challenging-or even contradictory-combinations of biomaterial properties are often required which cannot be met by conventional biomaterials. During the past decade, several new concepts have been developed to render biomaterials self-healing, thereby offering new opportunities to improve the functionality of traditional biomaterials in terms of their mechanical, handling, and biological properties. Consequently, various types of self-healing polymeric, ceramic, or composite biomaterials have been developed. Nevertheless, despite the rapid emergence of the field of self-healing biomaterials, this field of research has not been reviewed during the recent years. Therefore, this article provides a critical overview of recent progress in the field of self-healing biomaterials research by discussing both extrinsic and intrinsic self-healing systems. While the extrinsic self-healing section focuses on self-healing dental materials and orthopedic bone cements that rely on release of healing liquids from embedded microcapsules, the section on intrinsic self-healing materials mainly discusses concepts for self-healing of polymeric biomaterials that are either hydrated (hydrogels) or nonhydrated (e.g., films and coatings). Finally, benefits of the self-healing feature for biomaterials are discussed, and directions for future research and developments are outlined.

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Antibiotic‐Loaded Ultrahigh Molecular Weight Polyethylenes

Lekkala,

Inverardi,

Yuh

et al. 2024

Macromolecular Bioscience

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The occurrence of periprosthetic joint infections (PJI) after total joint replacement constitutes a great burden for the patients and the healthcare system. Antibiotic‐loaded polymethylmethacrylate (PMMA) bone cement is often used in temporary spacers during antibiotic treatment. PMMA is not a load‐bearing solution and needs to be replaced by a functional implant. Elution from the ultra‐high molecular weight polyethylene (UHMWPE) bearing surface for drug delivery can combine functionality with the release of clinically relevant doses of antibiotics. In this study, the feasibility of incorporating a range of antibiotics into UHMWPE is investigated. Drug stability is assessed by thermo‐gravimetric analysis and nuclear magnetic resonance spectroscopy. Drug‐loaded UHMWPEs are prepared by compression molding, using eight antibiotics at different loading. The predicted intra‐articular concentrations of drugs eluted from UHMWPE are above minimum inhibitory concentration for at least three weeks against Staphylococci, which are the major causative bacteria for PJI. The antibacterial efficacy is confirmed for samples covering 2% of a representative knee implant in vitro over 72 hours, showing that a small fraction of the implant surface loaded with antibiotics might be sufficient against Staphylococci.This article is protected by copyright. All rights reserved

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Autonomic Healing of Acrylic Bone Cement

Cited by 21 publications

References 39 publications

Autonomic healing of PMMA via microencapsulated solvent

Autonomic healing of PMMA via microencapsulated solvent

Self‐Healing Biomaterials: From Molecular Concepts to Clinical Applications

Antibiotic‐Loaded Ultrahigh Molecular Weight Polyethylenes

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