Using a multiaxial‐randomly loaded air‐suspension rear‐axle for commercial vehicles as an example, this paper gives an insight in the mechanics and interactions of wheel forces and moments, forces acting in the suspension components and the stress response of the axle casing. Taking load‐time and stress‐time data measured on a prototype vehicle on a test track as a basis, fatigue, frequency and correlation analyses for all relevant manoeuvres and straight‐ahead driving situations are performed. Special focus is given to the study and determination of appropriate correlations between the mentioned properties for manoeuvres and straight ahead driving on rough roads. The results point out all decisive load situations which may affect the fatigue behaviour of the axle under operational conditions and were taken into account for the derivation of optimized design solutions, as well as for the experimental verification of the final solution in the test rig.