Automation of selective assays for on-line bioprocess monitoring by flow-injection analysis

Pol, J.J. van der; Gooijer, C.D. de; Biselli, M.; Wandrey, Christian; Tramper, J.

doi:10.1016/s0167-7799(96)10065-2

Cited by 21 publications

(4 citation statements)

References 36 publications

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“…However, the selection of a suitable pump (piston, peristaltic, etc.) is important (Van der Pol et al, 1996;Vaidyanathan et al, 1999). SIA is an improvement of FIA (Christensen et al, 1996;Thomas et al, 1997).…”

Section: Automated Wet Chemistry Methodsmentioning

confidence: 99%

On-line monitoring equipment for wastewater treatment processes: state of the art

Vanrolleghem

Lee

2003

Water Science and Technology

164

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A (non-exhaustive) survey of new and existing technologies for the monitoring of wastewater treatment plants is presented. Emphasis is given to the way these sensors can provide insight in the ongoing (bio-) processes. Three different uses for sensors can be found: for monitoring (operator support), in automatic control systems and as tools for plant auditing/optimization/modelling by consultants. From this, sensors have been classified in two basic types: (i) reliable, simple and low maintenance sensors for day-to-day monitoring and control and (ii) advanced, higher maintenance sensors that are used in auditing, model calibration and optimisation. The paper is organized according to the typical unit processes of biological wastewater treatment systems: anaerobic digestion, activated sludge, nutrient removal and sedimentation. Attention is drawn to a number of practical problems associated with the use of sophisticated sensors in the harsh (dirty) conditions of wastewater treatment processes. The use of autocalibration and built-in sensor checks, cleaning systems and reliable sample preparation units is illustrated. The paper ends with a discussion of the applicability of the different sensors.

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Section: Automated Wet Chemistry Methodsmentioning

confidence: 99%

On-line monitoring equipment for wastewater treatment processes: state of the art

Vanrolleghem

Lee

2003

Water Science and Technology

164

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“…Especially biosensors are extremely interesting for a sensitive and selective monitoring of single components even in complex bioprocess media. Excellent reviews are available which describe the function in general and different samples of application of these sensor classes [1,6,[11][12][13][14][15][16].…”

Section: Bioprocess Monitoringmentioning

confidence: 99%

Bioanalytics: detailed insight into bioprocesses

Scheper

Hitzmann

Stärk

et al. 1999

Analytica Chimica Acta

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The principles of bioanalytical systems for an on-line bioprocess monitoring are described within this paper. These sensor systems can be interfaced to the bioprocess in different ways according to the needs of the single bioprocess. Modular systems are necessary, which can fit exactly to the needs of the single process. Invasive as well as non-invasive bioanalytical tools are described and discussed in detail. Immunosensors give the possibility to monitor high molecular weight components within short time intervals. Non-invasive optical sensors allow the direct monitoring of various analytes such as oxygen pH for the complex fluorescence behavior of the bioprocess medium. These so-called fluorescence sensors offer the possibility to monitor intra-as well as extracellular components without interfering with the bioprocess. An industrial example for the application of bioanalytical tools for a process optimization are presented in this application. Here a biosensor system is used to optimize the downstreaming of molasses on a technical scale. The economic as well ecological advantages are discussed.

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“…Flow injection analysis (FIA) [1] can be a very useful tool for online bioprocess monitoring [2][3][4][5][6][7][8][9]. If the determination of fluoride is aimed, potentiometry with a fluoride ion-selective electrode is the obvious choice for its measurement.…”

Section: Introductionmentioning

confidence: 99%

Development of flow injection potentiometric methods for the off-line and on-line determination of fluoride to monitor the biodegradation of a monofluorophenol in two bioreactors

Mesquita

Santos

Pedrosa

et al. 2011

Talanta

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Water treatment has become a source of concern as new pollutants and higher volumes of waste water must be treated. Emerging biological approaches, namely the use of bioreactors, for cleaning processes have been introduced. The use of bioreactors requires the development of efficient monitoring tools, preferably with real-time measurements. In this work, a couple of flow injection systems were developed and optimized for the potentiometric determination of fluoride to monitor a rotating biological contactor (RBC) bioreactor and a sequencing batch reactor (SBR) with off-line and on-line sampling. Both the RBC and the SBR bioreactors were set up for the biodegradation of the halogenated organic compound 2-fluorophenol and, as fluoride was a degradation byproduct, the process was monitored by following up its concentration. The described flow injection potentiometric methods enabled the fluoride determination within the required quantification range 0.10-100mM. The possible interferences from the growth medium were minimized in-line. The determination rate was 78 h(-1) for the off-line monitoring of RBC and 50(-1)h for the on-line monitoring of the SBR, with a sample consumption of 0.500 mL and 0.133 mL per determination, respectively. Furthermore, the overall reagent consumption was quite low. The accuracy of the system was evaluated by comparison with a batch procedure. The SBR efficiency was monitored both on-line by the flow system and off-line by HPLC, for comparison purposes.

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Automation of selective assays for on-line bioprocess monitoring by flow-injection analysis

Cited by 21 publications

References 36 publications

On-line monitoring equipment for wastewater treatment processes: state of the art

On-line monitoring equipment for wastewater treatment processes: state of the art

Bioanalytics: detailed insight into bioprocesses

Development of flow injection potentiometric methods for the off-line and on-line determination of fluoride to monitor the biodegradation of a monofluorophenol in two bioreactors

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