Modern state-of-the-art fatigue monitoring approaches gain in importance not only as part of the ageing management of nuclear power plant components but also in the context of conventional power plants and renewables such as wind power plants. Consequently, lots of operators have to deal with demanding security requirements to ensure the safe operation of power plants and to cope with plant lifetime extension (PLEX) related issues.AREVA disposes of a long tradition in the development of fatigue and structural health monitoring solutions. Nuclear and conventional power plant applications require the qualified assessment of measured thermo-mechanical loads. The methodology is transferable to mechanical loading conditions such as those of wind energy plants. The core challenge is the identification and qualified processing of realistic load-time histories. The related methodological requirements will be explained in detail. This paper mainly describes the fatigue and structural health methodologies developed within the AREVA Fatigue Concept (AFC).