Automatic determination of quinine by atomic absorption spectrometry

Yebra, M. C.; Cespón, R. M.

doi:10.1016/s0026-265x(00)00034-5

Cited by 18 publications

(9 citation statements)

References 21 publications

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“…[13] Several methods were proposed, mostly for the concrete determination of quinine in soft drinks. These techniques include atomic absorption spectrometry (indirect determination) with reversed flow injection system, [14] flow through sensor with fluorimetric transduction, [15] isotachophoresis with UV and conductivity detection, [16] 4th-order derivative spectrophotometric, [17] spectrophotometric, [18] fluorimetry, [19,20] plasticized poly(vinyl chloride) membrane electrode with direct potentiometry, [21] optosensor with C 18 silica gel as substrate in conjunction with a flow injection analysis system, [22] cyclic voltammetry, [23] and immunoassay. [24] In this paper a simple, rapid, and sensitive method was developed for the routine determination of quinine based on high performance liquid chromatography (HPLC) with LIF detection.…”

Section: Fast and Sensitive New High Performance Liquidmentioning

confidence: 99%

Fast and Sensitive New High Performance Liquid Chromatography Laser Induced Fluorescence (HPLC-LIF) Method for Quinine. Comparative Study in Soft Drinks

Feás

Fente

Cepeda

2009

Journal of Liquid Chromatography & Related Technologies

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A simple, quick, and accurate new method for the determination of quinine (6 0 -methoxycinchonan-9-ol) in soft drinks is presented. The analysis is carried out using high performance liquid chromatography (HPLC), coupled laser induced fluorescence (LIF) that consisted of a 325 nm He-Cd laser and a ZETALIF detector. The chromatographic separation was performed on a Phenomenex Synergi Fusion-Reversed Phase (RP) column and allows good peak shape and symmetry in less than 1.5 min. A calibration curve ranging from 1 to 100 ng=mL was shown to be linear with a correlation coefficient (R) of 0.9999. The limit of detection of quinine was 3.2 pg on the column. The method was applied to the analysis of several beverages (n ¼ 43) containing quinine, whose analysis required minimum pretreatment before direct injection, and can therefore be used for quality control in comparison to the classical methods. Data obtained from different commercial beverages containing quinine show no homogeneous concentration of this compound. This article describes, for the first time, the successful application of HPLC coupled LIF detection for quinine determination in common beverages.

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Section: Fast and Sensitive New High Performance Liquidmentioning

confidence: 99%

Fast and Sensitive New High Performance Liquid Chromatography Laser Induced Fluorescence (HPLC-LIF) Method for Quinine. Comparative Study in Soft Drinks

Feás

Fente

Cepeda

2009

Journal of Liquid Chromatography & Related Technologies

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“…These threshold limits of QN toxicity may favor the importance of accurate biomonitoring techniques for estimating its levels in body fluids. Several procedures have been proposed for the determination of QN involving chemiluminescence [7,8], isotachophoresis [9], fluorimetry [10 -13], photometry [14 -16], potentiometry [17 -22], high performance liquid chromatography [23 -25], atomic absorption spectrometry [26] (indirect determination) and gas chromatography/mass spectrometry [27].…”

mentioning

confidence: 99%

Flow‐Through Assay of Quinine Using Solid Contact Potentiometric Sensors Based on Molecularly Imprinted Polymers

Kamel

Sayour²

2009

Electroanalysis

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Miniaturized potentiometric membrane sensors for quinine incorporated with molecular imprinted polymer (MIP) were synthesized and implemented. Planar PVC based polymeric membrane sensors containing quinine-methacrylic and/or acrylic acid-ethylene glycol methacrylate were dispensed into anisotropically etched wells on polyimide wafers. The determination of quinine was carried out in acidic solution at pH 6, where positively charged species predominated prevalently. The suggested miniaturized planner sensors exhibited marked selectivity, sensitivity, longterm stability and reproducibility. At their optimum conditions, the sensors displayed wide concentration ranges of 4.0 Â 10with slopes of about 61.3 -55.7 mV decade À1 ; respectively. Sensors exhibit detection limits of 1.2 Â 10 À6 and 8.2 Â 10 À6 mol L À1 upon the use of methacrylic and acrylic acid monomers in the imprinted polymer, respectively. Validation of the assay method according to the quality assurance standards (range, within-day repeatability, between-day variability, standard deviation, accuracy, and good performance characteristics) which could assure good reliable novel sensors for quinine estimation was justified. Application of the proposed flow-through assay method for routine determination of quinine in soft drinks was assayed and the results compared favorably with data obtained by the standard fluorimetric method.

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“…In this context, ultrasound energy is of great help in the sample pretreatment. This energy facilitates and accelerates some analytical steps such as sample preparation, among others (14)(15). Nevertheless, these off-line procedures are laborious and time-consuming because they involve large sonication times as well as a centrifugation step to separate the liquid phase.…”

Section: Introductionmentioning

confidence: 99%

Flow Injection Determination of Calcium and Magnesium in Soluble Pharmaceutical Tablets by Flame Atomic Absorption Spectrometry Using Ultrasound for Sample Preparation

Yebra¹

2011

At.Spectrosc.

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A simple and rapid continuous manifold for sample dissolution based on ultrasound energy is evaluated for flow injection determination of calcium and magnesium in pharmaceutical tablets by flame atomic absorption spectrometry. Several parameters that could influence the dissolution process were evaluated by Plackett-Burman experimental designs. The obtained results showed that samples were easily dissolved with ultrapure water at room temperature at a flow-rate of 6 mL min -1 under the action of ultrasound energy during 30 seconds. The analytical method was characterized and the limit of detection and limit of quantification for the two metals were 2.8 and 9.5 mg g -1 for Ca and 7.5 and 25 µg g -1 for Mg, respectively. The sampling frequency of the system was about 50 samples per hour, with repeatability, expressed as relative standard deviation, in the range 0.5 and 3.0% for both metals. The proposed methodology was successfully applied to determine calcium and magnesium in multivitamin tablets.

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Automatic determination of quinine by atomic absorption spectrometry

Cited by 18 publications

References 21 publications

Fast and Sensitive New High Performance Liquid Chromatography Laser Induced Fluorescence (HPLC-LIF) Method for Quinine. Comparative Study in Soft Drinks

Fast and Sensitive New High Performance Liquid Chromatography Laser Induced Fluorescence (HPLC-LIF) Method for Quinine. Comparative Study in Soft Drinks

Flow‐Through Assay of Quinine Using Solid Contact Potentiometric Sensors Based on Molecularly Imprinted Polymers

Flow Injection Determination of Calcium and Magnesium in Soluble Pharmaceutical Tablets by Flame Atomic Absorption Spectrometry Using Ultrasound for Sample Preparation

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