Abstract:An automatic method able to recognize a presented section through the biparietal plane of the fetal head and a section through the fetal femur in ultrasound images is developed. Once the correct anatomical section for measurement is identified by the machine, the placement of the measurement calipers is automatically determined by fitting an active contour model to the structure of interest. The fetal biparietal diameter (BPD) and femur length (FL) are then measured automatically. The validation data set conta… Show more
“…To summarize, while biometric linear measurements of the fetal brain are an essential part of fetal development assessment, they are currently performed manually. While automatic methods for the computation of US-based biometric linear measurements are available, e.g., biparietal diameter [21,22], fetal head circumference [23] and femur length [21], no such methods are available for fetal MRI.…”
Section: Mid-sagittal Line (Msl) Computationmentioning
Purpose: Timely, accurate and reliable assessment of fetal brain development is essential to reduce short and longterm risks to fetus and mother. Fetal MRI is increasingly used for fetal brain assessment. Three key biometric linear measurements important for fetal brain evaluation are Cerebral Biparietal Diameter (CBD), Bone Biparietal Diameter (BBD), and Trans-Cerebellum Diameter (TCD), obtained manually by expert radiologists on reference slices, which is time consuming and prone to human error. The aim of this study was to develop a fully automatic method computing the CBD, BBD and TCD measurements from fetal brain MRI.
Methods:The input is fetal brain MRI volumes which may include the fetal body and the mother's abdomen. The outputs are the measurement values and reference slices on which the measurements were computed. The method, which follows the manual measurements principle, consists of five stages: 1) computation of a Region Of Interest that includes the fetal brain with an anisotropic 3D U-Net classifier; 2) reference slice selection with a Convolutional Neural Network; 3) slice-wise fetal brain structures segmentation with a multiclass U-Net classifier; 4) computation of the fetal brain midsagittal line and fetal brain orientation, and; 5) computation of the measurements.
Results:Experimental results on 214 volumes for CBD, BBD and TCD measurements yielded a mean 𝐿 1 difference of 1.55mm, 1.45mm and 1.23mm respectively, and a Bland-Altman 95% confidence interval (𝐶𝐼 95 ) of 3.92mm, 3.98mm and 2.25mm respectively. These results are similar to the manual inter-observer variability, and are consistent across gestational ages and brain conditions.
Conclusions:The proposed automatic method for computing biometric linear measurements of the fetal brain from MR imaging achieves human level performance. It has the potential of being a useful method for the assessment of fetal brain biometry in normal and pathological cases, and of improving routine clinical practice.
“…To summarize, while biometric linear measurements of the fetal brain are an essential part of fetal development assessment, they are currently performed manually. While automatic methods for the computation of US-based biometric linear measurements are available, e.g., biparietal diameter [21,22], fetal head circumference [23] and femur length [21], no such methods are available for fetal MRI.…”
Section: Mid-sagittal Line (Msl) Computationmentioning
Purpose: Timely, accurate and reliable assessment of fetal brain development is essential to reduce short and longterm risks to fetus and mother. Fetal MRI is increasingly used for fetal brain assessment. Three key biometric linear measurements important for fetal brain evaluation are Cerebral Biparietal Diameter (CBD), Bone Biparietal Diameter (BBD), and Trans-Cerebellum Diameter (TCD), obtained manually by expert radiologists on reference slices, which is time consuming and prone to human error. The aim of this study was to develop a fully automatic method computing the CBD, BBD and TCD measurements from fetal brain MRI.
Methods:The input is fetal brain MRI volumes which may include the fetal body and the mother's abdomen. The outputs are the measurement values and reference slices on which the measurements were computed. The method, which follows the manual measurements principle, consists of five stages: 1) computation of a Region Of Interest that includes the fetal brain with an anisotropic 3D U-Net classifier; 2) reference slice selection with a Convolutional Neural Network; 3) slice-wise fetal brain structures segmentation with a multiclass U-Net classifier; 4) computation of the fetal brain midsagittal line and fetal brain orientation, and; 5) computation of the measurements.
Results:Experimental results on 214 volumes for CBD, BBD and TCD measurements yielded a mean 𝐿 1 difference of 1.55mm, 1.45mm and 1.23mm respectively, and a Bland-Altman 95% confidence interval (𝐶𝐼 95 ) of 3.92mm, 3.98mm and 2.25mm respectively. These results are similar to the manual inter-observer variability, and are consistent across gestational ages and brain conditions.
Conclusions:The proposed automatic method for computing biometric linear measurements of the fetal brain from MR imaging achieves human level performance. It has the potential of being a useful method for the assessment of fetal brain biometry in normal and pathological cases, and of improving routine clinical practice.
“…This device is aimed to be used by trained ultrasound operators and midwives trained, or undergoing training, in ultrasound in LMIC. As a follow-up of our prior work [22] [23] on automatizing BPD, FL and fetal abdominal measurements, the aim of this study is to develop a fully automatic method for detecting and measuring the fetal abdominal section in a B-mode ultrasound image, and for measuring the MAD or AC. The method is designed to be run on a low cost, easy-to-use portable ultrasound machine suited for use in LMIC.…”
An automatic method for measuring the fetal mean abdominal diameter (MAD) or abdominal circumference (AC) with ultrasound is proposed. From a correctly presented abdominal section suitable for MAD or AC measurement, the location of fetal abdomen is detected by image processing. Thereafter, an active contour model is converged along the abdominal boundary for measurement purposes. The validation data set contained 310 images of fetuses with gestational age (GA) from 14 to 41 weeks. The measurement success rate was 88.1%. By manually indicating the location of the abdomen, the success rate was further improved to 95.8% for the failed cases. The correlation between manual and automatic measurements was 0.95 and the intraclass correlation coefficient (ICC) was 0.976 (95% confidence interval (CI); 0.969 -0.981). The average method execution time was 0.3 s. The mean error was lower in young fetuses (0.4%) than in older fetuses (−2.1%). The proposed cross-platform method was implemented on a portable, low-cost ultrasound machine prototype targeted for low-and middle-income countries (LMIC); the results achieved were comparable to those of other state-of-the-art automatic methods.
“…There is extensive work on segmentation of anatomical structures in standard US planes, specifically those concerning second and third trimester screening [19]. These techniques can support automated fetal biometry, including measurements on the head [24,13,16,23,15,4], femur [15,12], and abdominal section [14]. These methods, however, rely on prior knowledge of which measurement to perform on a given image.…”
Section: Introductionmentioning
confidence: 99%
“…A fully automated biometry system should both identify which standard plane is being imaged and whether it is of sufficient quality to perform the relevant measurements. Automatic image quality assessment has been investigated, including adequate magnification, symmetry and the visibility of relevant anatomical structures within the image [17,15]. Such methods together with classification of standard planes [1] can be used to extract appropriate planes for fetal biometry from US video or image collections [9].…”
During pregnancy, ultrasound examination in the second trimester can assess fetal size according to standardized charts. To achieve a reproducible and accurate measurement, a sonographer needs to identify three standard 2D planes of the fetal anatomy (head, abdomen, femur) and manually mark the key anatomical landmarks on the image for accurate biometry and fetal weight estimation. This can be a timeconsuming operator-dependent task, especially for a trainee sonographer. Computer-assisted techniques can help in automating the fetal biometry computation process. In this paper, we present a unified automated framework for estimating all measurements needed for the fetal weight assessment. The proposed framework semantically segments the key fetal anatomies using state-of-the-art segmentation models, followed by region fitting and scale recovery for the biometry estimation. We present an ablation study of segmentation algorithms to show their robustness through 4-fold cross-validation on a dataset of 349 ultrasound standard plane images from 42 pregnancies. Moreover, we show that the network with the best segmentation performance tends to be more accurate for biometry estimation. Furthermore, we demonstrate that the error between clinically measured and predicted fetal biometry is lower than the permissible error during routine clinical measurements.
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