“…Commonly utilized purification strategies are SPE with different stationary phase materials (e.g. C18, HILIC, and PGC), paper chromatography (Bigge et al, 1995), filtration (Hase, 1994; Prater, Anumula, & Hutchins, 2007), dialysis and precipitation (Pabst, Kolarich, Poltl, Dalik, Lubec, Hofinger et al, 2009). Unfortunately, the introduction of an additional purification step reduces sample preparation throughput and creates the potential for sample loss.…”