Automated fermentation equipment II. Computer–fermentor system

Nyeste, L.; Szigeti, L.; Veres, Anita; Püngor, E.; Kurucz, I.; Holló, J.

doi:10.1002/bit.260230214

Cited by 17 publications

(2 citation statements)

References 7 publications

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“…Holló/University of Technical Sciences (Budapest) 1981 Nyeste et al (1981) On-line volumetric mass transfer coefficient calculation using static method.…”

Section: Hansenula Anomalamentioning

confidence: 99%

Bioprocess monitoring and computer control: Key roots of the current PAT initiative

Junker

Wang

2006

Biotech & Bioengineering

113

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This review article has been written for the journal, Biotechnology and Bioengineering, to commemorate the 70th birthday of Daniel I.C. Wang, who served as doctoral thesis advisor to each of the co-authors, but a decade apart. Key roots of the current PAT initiative in bioprocess monitoring and control are described, focusing on the impact of Danny Wang's research as a professor at MIT. The history of computer control and monitoring in biochemical processing has been used to identify the areas that have already benefited and those that are most likely to benefit in the future from PAT applications. Past applications have included the use of indirect estimation methods for cell density, expansion of on-line/at-line and on-line/in situ measurement techniques, and development of models and expert systems for control and optimization. Future applications are likely to encompass additional novel measurement technologies, measurements for multi-scale and disposable bioreactors, real time batch release, and more efficient data utilization to achieve process validation and continuous improvement goals. Dan Wang's substantial contributions in this arena have been one key factor in steering the PAT initiative towards realistic and attainable industrial applications.

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“…Holló/University of Technical Sciences (Budapest) 1981 Nyeste et al (1981) On-line volumetric mass transfer coefficient calculation using static method.…”

Section: Hansenula Anomalamentioning

confidence: 99%

Bioprocess monitoring and computer control: Key roots of the current PAT initiative

Junker

Wang

2006

Biotech & Bioengineering

113

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“…28 Nakai" compared different optimization methods in food production and demonstrated the effectiveness of the simplex method in terms of the small number of iterations required. Nyests et al 30 applied the simplex method developed by Nelder-Mead for on-line optimization of fermentation processes. Other examples of modeling of fermentation processes by factorial analysis, surface methodology, and off-line optimization of processes by simplex or complex methods in wastewater treatment can be found elsewhere.…”

Section: Introductionmentioning

confidence: 99%

On‐line optimization of biotechnological processes: I. Application to open algal pond

Guterman

Ben‐Yaakov

1990

Biotech & Bioengineering

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A new on-line optimization and control procedure applicable to biotechnological systems for which a precise mathematical model is unavailable has been developed and tested. The proposed approach is based on an online search for optimum operating conditions by an automatic system using a modified simplex algorithm to which several features have been added to permit real time operation. The simplex algorithm is the upper level of a hierarchical software package in which the other levels are cost evaluation, control, data acquisition, and signal processing. The optimization method was tested in a laboratory minipond for the cultivation of Spirulina platensis. The controlled parameters were light intensity, optical density, pH, and temperature. The proposed optimization method can be applied to other biological processes provided that the pertinent variables can be measured and controlled and the cost function can be defined mathematically.

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Mikrocomputer‐unterstützte prozeßkontrolle in der fermentationstechnik

Bayer¹

1984

Acta Biotechnologica

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Automated fermentation equipment II. Computer–fermentor system

Cited by 17 publications

References 7 publications

Bioprocess monitoring and computer control: Key roots of the current PAT initiative

Bioprocess monitoring and computer control: Key roots of the current PAT initiative

On‐line optimization of biotechnological processes: I. Application to open algal pond

Mikrocomputer‐unterstützte prozeßkontrolle in der fermentationstechnik

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