In this paper a new approach of breast microcalcifications diagnosis on digital mammograms is introduced. The proposed approach begins with a preprocessing procedure aiming artifacts and pectoral muscle removal based on morphologic operators and contrast enhancement based on galactophorous tree interpolation.The second step of the proposed CAD system consists on segmenting microcalcifications clusters, using Generalized Gaussian Density (GGD) estimation and a Bayesian backpropagation neural network.The last step is microcalcifications characterization using morphologic features which are used to feed a neuro-fuzzy system to classify the detected breast microcalcifications into benign and malignant classes.