Autologous serum Therapy of the ocular surface with Novel Delivery by Platelet Concentrate Gel

The Role of Platelet Gel in Regenerative Medicine

“…Platelet gel has been successfully used for ocular diseases, such as for enhanced healing of corneal surface and ocular surgery (Koffler, 2006;Liu et al,2006;Lee & Kang, 2011). Lately, the studies of PG use addressed some unexpected fields of medicine.…”

Autologous serum for ocular surface diseases

“…However, the most standardized dilution of autologous serum is at 20% which is based on the concentration of certain growth factors in tears (2,7) . It also seems to avoid the irritation derived from the higher viscosity in concentrated preparations and may act favorably by reducing the number of blood extraction procedures (4) . Table 2 describes the variation in storage, preparation and application published in the literature.…”

“…Autologous serum eye drops have been recommended for the treatment of several ocular surface disturbances, such as Sjögren's syndrome-related tear deficiency, non-Sjögren's tear deficiency associated with graft-versus-host disease, neurotrophic keratitis, persistent epithelial defects, superior limbic keratoconjunctivitis, as well as a supportive measure in ocular surface reconstruction (4) . Its utilization in Ophthalmology arose out of the need of finding lacrimal substitutes which, in addition to lubricating the ocular surface, were able to provide other components of tears that are reduced in ocular surface disease (5) .…”

“…Human serum contains substances such as epidermal growth factor, vitamin A, transforming growth factor-β, fibronectin, and cytokines normally found in tears. These factors are important for maintaining a healthy corneal and conjunctival epithelium (4) . This review summarizes the recently published literature on the ocular surface diseases treated with autologous serum.…”

Advances in Regenerative Medicine

“…Platelet gel has been successfully used for ocular diseases, such as for enhanced healing of corneal surface and ocular surgery (Koffler, 2006;Lee & Kang, 2011). Lately, the studies of PG use addressed some unexpected fields of medicine.…”