The Role of Platelet Gel in Regenerative Medicine

Rožman, Primož; Semenič, Danijela; Smrke, Dragica

doi:10.5772/26130

Cited by 8 publications

(21 citation statements)

References 86 publications

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“…Autologous platelet concentrates are promising in the field of regenerative medicine 18 because of the abundance of growth factors. However, these preparations often lacked a defined structure that makes surgical manipulation very difficult.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

Madurantakam

Yoganarasimha

Hasan

2015

JoVE

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Autologous platelet concentrates represent promising innovative tools in the field of regenerative medicine and have been extensively used in oral surgery. Unlike platelet rich plasma (PRP) that is a gel or a suspension, Leukocyte-Platelet Rich Fibrin (L-PRF) is a solid 3D fibrin membrane generated chair-side from whole blood containing no anti-coagulant. The membrane has a dense three dimensional fibrin matrix with enriched platelets and abundant growth factors. L-PRF is a popular adjunct in surgeries because of its superior handling characteristics as well as its suturability to the wound bed. The goal of the study is to demonstrate generation as well as provide detailed characterization of relevant properties of L-PRF that underlie its clinical success. Video LinkThe video component of this article can be found at

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Section: Discussionmentioning

confidence: 99%

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

Madurantakam

Yoganarasimha

Hasan

2015

JoVE

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“…However, they are now known for a myriad of diverse functions, cytokine signalling, chemokine and GF release, human mesenchymal stem cells (hMSC) mitogenesis and thus contributing significantly to tissue renewal. The PRP studies over the past decade originated as case studies that focused on clinical outcomes and gradually progressed to randomised control trials that also distinguished between the biochemical and biological mechanisms underlying these outcomes [6].…”

Section: Prp Nomenclaturementioning

confidence: 99%

Effects of platelet-rich plasma and platelet-poor plasma on human dermal fibroblasts

et al. 2018

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Platelet Rich Plasma is an autologous and safe blood product containing a high concentration of platelets and leucocytes, in a small volume of plasma. Platelets, growth factors, leucocytes and plasma are fundamental fibroblast proliferation agents. The leucocytes' plasticity, reparative qualities, their cross-talk between cells and capacity to orchestrate such diverse outcomes is receiving a considerable commendation. This succession enables fibroblast cells to migrate and proliferate into the wound's surrounding tissue and subsequently deposit granulation tissue to facilitate minimal scarring and also for anti-ageing benefits. The focus on leucocytes in tissue repair has enthused a new approach to tissue regeneration to form a new therapeutic modality, Immuno-Regenerative Medicine.

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“…This is the onset of PGF-mediated stimulation of cell proliferation, promotion of cell differentiation and chemotaxis, and induction of migration of various (stem) cells to the wound area [31,32]. The rational for applying PRP-G to wound bed tissues is the delivery of a diversity of concentrated platelet-derived growth factors and other biological mediators (e.g., adhesive proteins, fibrinogen, fibronectin, vitronectin, and thrombospondin-1) to mimic, and accelerate, physiologic wound healing cascades and regenerative tissue repair processes ( Figure 2) [33].…”

Section: Platelet-rich Plasma Gel Growth Factors and Platelet Recepmentioning

confidence: 99%

Autologous Platelet-Rich Plasma and Mesenchymal Stem Cells for the Treatment of Chronic Wounds

Everts¹

2019

Wound Healing - Current Perspectives

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Emerging autologous cellular therapies, utilizing platelet-rich plasma and mesenchymal stem cell applications, have the potential to play an adjunctive role in a standardized wound care treatment plan in patients suffering from chronic and recalcitrant wounds. The use of platelet-rich plasma growth is based on the fact that platelet growth factors can support the three phases of wound healing and then ultimately contribute to full wound closure. Mesenchymal stem cell-based therapies are also an attractive approach for the treatment of these difficult-to-heal wounds. This field of regenerative medicine focuses primarily on stem cells, which are specialized cells with the ability to self-renew and differentiate into multiple cell types. Mesenchymal stem cells can be isolated from bone marrow and adipose tissue via minimally manipulative and cell-processing techniques, at point of care. Both platelet-rich plasma and mesenchymal stem cell applications have the potential to become an effective and ideal autologous biological cell-based therapy, which can be applied to chronic wounds to effectively change the wound bed microenvironment to enable and accelerate wound closure.

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The Role of Platelet Gel in Regenerative Medicine

Cited by 8 publications

References 86 publications

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

Effects of platelet-rich plasma and platelet-poor plasma on human dermal fibroblasts

Autologous Platelet-Rich Plasma and Mesenchymal Stem Cells for the Treatment of Chronic Wounds

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