Autologous Platelet-rich Plasma Eye Drops in the Treatment of Recurrent Corneal Erosions

Abstract

PurposeTo evaluate the effect of platelet-rich plasma (PRP) eye drops in the treatment of recurrent corneal erosions (RCE).MethodsA total of 47 eyes were included in this retrospective study. Clinical records of 20 consecutive patients with RCE who had been treated with conventional lubricant eye drops (conventional treatment group) from June 2006 to December 2008 and 27 consecutive patients treated with autologous PRP eye drops in addition to lubricant eye drops (PRP eye drops treated group) from January 2009 to September 2014 were reviewed. Major and minor recurrences were recorded and compared between two groups.ResultsThis study included 31 men and 16 women. The mean age was 44.5 ± 14.5 years (range, 19 to 86 years), and the mean follow-up duration was 14.9 ± 14.4 months (range, 6 to 64 months). Of the 27 cases in the PRP eye drops treated group, there were seven major recurrences in six eyes (22.2%) and ten minor recurrences in seven eyes (25.9%). In contrast, 16 eyes (80.0%) from the 20 patients in the conventional lubricant eye drops treated group had major recurrences, and all patients in this group reported minor recurrences. The mean frequency of recurrence was 0.06 ± 0.08 per month in the PRP eye drops treated group and 0.39 ± 0.24 per month in the conventional treatment group (p = 0.003). No side effects were noted in any of the patients over the follow-up period.ConclusionsThe use of PRP eye drops for the treatment of RCE was shown to be effective in reducing the recurrence rate without any significant complications.

Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study

“…The aim of this study was to evaluate the effectiveness of intrauterine infusion of PRP in the treatment of thin endometrium in FET cycles (El-Anwar et al. , 2016; Lee et al. , 2016; Maria-Angeliki et al , 2015; Picard et al , 2015; Ronci et al , 2015; Rossi et al , 2016; Sadabad et al , 2016).…”

Recurrent Corneal Erosions in Corneal Dystrophies: a Review of the Pathogenesis, Differential Diagnosis, and Therapy

“…The oil present in the serum may act as a suitable substitute for the lipid components produced by Meibomian glands, and pre-albumin contributes to the stability of the tear film. Clinical trials have shown that autologous serum can be used to effectively treat RCE [35].…”

Regenerative Therapies in Dry Eye Disease: From Growth Factors to Cell Therapy

“…In 1984, its first successful use in patients with dry eye was described [ 19 ]. However, from the works of Tsubota et al [ 20 , 21 ] in 1999, AS application gained widespread acceptance as an adjuvant therapy in different ocular surface disorders [ 3 , 15 , 22 , 23 ].…”

“…The therapeutic advantages of AS use as a substitute for tears are given by their similarity in certain characteristics, such as pH, osmolality, and biomechanical characteristics. AS fulfills a lubricating function and performs anti-inflammatory, antimicrobial, and epitheliotrophic functions through certain biomolecules of its composition similar to natural tears [ 13 , 23 ] ( Table 1 ).…”

“…In AS, composition is emphasized; various substances are present which also exist in normal tears, including growth factors such as transforming growth factor (TGF-β), platelet-derived growth factors (PDGF), epidermal growth factor (EGF), nerve growth factor, and insulin-like growth factor 1; neurotrophic factors (substance P); cytokines; bacteriostatic factors (lactoferrin, lysozyme, immunoglobulins); fibronectin and vitamin A and E [ 13 , 23 , 24 ] ( Table 1 ). Some of them have an increased concentration with respect to natural tears, such as vitamin A, lysozyme, TGF-β, and fibronectin, and some components are present in lesser concentrations, such as immunoglobulin A, epithelial EGF, and vitamin C [ 15 , 23 , 24 ].…”