Autologous Platelet‐Rich Fibrin in the Treatment of 3‐Wall Intrabony Defects in Aggressive Periodontitis: A Randomized Controlled Clinical Trial

Bajaj, Pavan; Agarwal, Esha; Rao, Nishanth S.; Naik, Savitha B.; Pradeep, A.R.; Kalra, Nitish; Priyanka, N; Kumari, Minal

doi:10.1902/jop.2017.120661

Cited by 29 publications

(34 citation statements)

References 35 publications

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“…To ensure adequate intraexaminer reproducibility, the examiner was calibrated before the beginning of the study in some trials. [ 2 , 3 , 5 – 7 , 12 , 13 , 15 ] Three studies were placebo-controlled, triple-masked trials. [ 2 , 12 , 14 ] Three studies were double–blinded clinical trials.…”

Section: Resultsmentioning

confidence: 99%

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Additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects

Yang

Zhang

et al. 2019

Medicine

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Background:This meta-analysis was performed to determine the additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects in chronic periodontitis patients.Methods:Pertinent studies were identified by a search in Medline, EMBASE, the Web of Science, and the Cochrane Library. The trials searched were evaluated for eligibility. Cochrane Collaboration's Review Manager software was used to perform the meta-analyses.Results:Twelve eligible clinical trials were included. Pooled data found that adjunctive platelet-rich fibrin exactly yielded a significantly superior probing depth reduction compared with open flap debridement alone (weighted mean difference, 1.01; 95% confidence interval 0.95–1.08; P < .00001). The clinical attachment level (CAL) gain after treatment for 9 months was higher in patients treated with platelet-rich fibrin plus open flap debridement group than in open flap debridement-treated patients (weighted mean difference, 1.29; 95% confidence interval 0.96– 1.61; P < .00001). Similarly, the meta-analysis demonstrated that platelet-rich fibrin was superior to single open flap debridement with respect to gingival marginal level change (weighted mean difference, 0.45; 95% confidence interval 0.31–0.58; P < .00001). Regarding the hard tissue radiographic parameters, including defect depth reduction and percentage of fill defects in bone, adjunctive platelet-rich fibrin yielded significantly superior results compared with open flap debridement alone.Conclusion:Adjunctive use of platelet-rich fibrin with open flap debridement significantly improves fill defects when compared to open flap debridement alone. However, additional powered studies with much larger sample sizes are needed to obtain a more concrete conclusion.

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Section: Resultsmentioning

confidence: 99%

“…[ 2 , 12 , 14 ] Three studies were double–blinded clinical trials. [ 13 , 15 , 16 ] The details of the risk of bias are illustrated in Figure 7 .…”

Section: Resultsmentioning

confidence: 99%

Additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects

Yang

Zhang

et al. 2019

Medicine

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“…However, other three tooth extraction trials showed no significant difference in bone formation between PRF and blank control groups [48, 49] or between PRF and PRP on radiographic evaluation [50]. In controlled trials of inflammation-induced bone defect, two randomized controlled trials (RCTs) [51, 52] proved that PRF enhanced bone fill in IBD compared with open flap debridement (OFD) only. In a study, 13 patients with 26 IBD sites were divided into the PRF or OFD alone groups; the percentage of bone fill in PRF sites was 45.18% ± 7.57%, while the percentage of bone fill in OFD sites was 21.6% ± 9.3% ( p = 0.001) on radiographic evidence at 12 months [51].…”

Section: Effect Of Prf On Human Oral and Maxillofacial Bone Regenementioning

confidence: 99%

“…In a study, 13 patients with 26 IBD sites were divided into the PRF or OFD alone groups; the percentage of bone fill in PRF sites was 45.18% ± 7.57%, while the percentage of bone fill in OFD sites was 21.6% ± 9.3% ( p = 0.001) on radiographic evidence at 12 months [51]. In another study, 17 patients with 54 IBD sites were divided into the PRF or OFD alone group, and PRF (46.14% ± 11.39%) caused a greater percentage change in IBD depth than at the OFD sites (15.76% ± 18.77%) at 9 months ( p < 0.001) [52] radiologically. However, a controlled trial [53] revealed that PRF did not contribute to bone regeneration radiographically.…”

Section: Effect Of Prf On Human Oral and Maxillofacial Bone Regenementioning

confidence: 99%

Platelet-Rich Fibrin as a Bone Graft Material in Oral and Maxillofacial Bone Regeneration: Classification and Summary for Better Application

Liu

Sun

et al. 2019

BioMed Research International

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Platelet-rich fibrin (PRF) is an autologous platelet concentrate that consists of cytokines, platelets, leukocytes, and circulating stem cells. It has been considered to be effective in bone regeneration and is mainly used for oral and maxillofacial bone. Although currently the use of PRF is thought to support alveolar ridge preservation, there is a lack of evidence regarding the application of PRF in osteogenesis. In this paper, we will provide examples of PRF application, and we will also summarize different measures to improve the properties of PRF for achieving better osteogenesis. The effect of PRF as a bone graft material on osteogenesis based on laboratory investigations, animal tests, and clinical evaluations is first reviewed here. In vitro, PRF was able to stimulate cell proliferation, differentiation, migration, mineralization, and osteogenesis-related gene expression. Preclinical and clinical trials suggested that PRF alone may have a limited effect. To enlighten researchers, modified PRF graft materials are further reviewed, including PRF combined with other bone graft materials, PRF combined with drugs, and a new-type PRF. Finally, we will summarize the common shortcomings in the application of PRF that probably lead to application failure. Future scientists should avoid or solve these problems to achieve better regeneration.

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“…PRF is a fibrin 3-D polymerized matrix in which platelet cytokine, leucocytes, growth factors (like PDGFs, TGFβ, epidermal growth factor EGF and insulin like growth factor-1, IGF-1) and presence of circulating stem cells are trapped [11,12]. It has been defined as an autologous leucocyte and platelet rich fibrin biomaterial.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Split Mouth Clinical Evaluation of Amniotic Membrane and Platelet Rich Fibrin in Patients with Gingival Recession: Two Case Reports

Bansal¹

2018

Dentistry

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Autologous Platelet‐Rich Fibrin in the Treatment of 3‐Wall Intrabony Defects in Aggressive Periodontitis: A Randomized Controlled Clinical Trial

Abstract: Within the limits of the present study, there is greater bone fill at sites treated with PRF with conventional OFD than conventional OFD alone.

Cited by 29 publications

References 35 publications

Additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects

Additive effectiveness of autologous platelet-rich fibrin in the treatment of intrabony defects

Platelet-Rich Fibrin as a Bone Graft Material in Oral and Maxillofacial Bone Regeneration: Classification and Summary for Better Application

A Comparative Split Mouth Clinical Evaluation of Amniotic Membrane and Platelet Rich Fibrin in Patients with Gingival Recession: Two Case Reports

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