Autologous platelet-derived wound healing factor promotes angiogenesis via alphavbeta3-integrin expression in chronic wounds.

Herouy, Yared; Mellios, P; Bandemir, E; Stetter, Christian; Dichmann, Stefan; Idzko, Marco; Hofmann, Christopher M.; Vanscheidt, Wolfgang; Schöpf, Erwin; Norgauer, Johannes

doi:10.3892/ijmm.6.5.515

Cited by 19 publications

(15 citation statements)

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“…Autologous PRP to promote wound healing has been introduced for medical purposes because of its abundance of growth factors (Wang et al 1996;Moulin et al 1998;Herouy et al 2000;Margolis et al 2001). Since the case report of human mandibular reconstruction was introduced (Marx et al 1998), the applications of PRP and fibrin glue have been introduced in various dental procedures, for example in sinus floor augmentations (Kassolis et al 2000;Rosenberg & Torosian 2000;Lozada et al 2001;Froum et al 2002;Rodriguez et al 2003;Schlegel et al 2003), periodontal regenerations (de Obarrio et al 2000;Camargo et al 2002;Lekovic et al 2003), dental implantations and oral surgical procedures (Anitua 1999;Vercellotti 2000;Shanaman et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Releasing growth factors from activated human platelets after chitosan stimulation: a possible bio‐material for platelet‐rich plasma preparation

Shen

Chou

Gau³

et al. 2006

Clinical Oral Implants Res

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Section: Discussionmentioning

confidence: 99%

Releasing growth factors from activated human platelets after chitosan stimulation: a possible bio‐material for platelet‐rich plasma preparation

Shen

Chou

Gau³

et al. 2006

Clinical Oral Implants Res

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“…PDWHF has also been used to treat leg ulcers in the setting of β-thalasemia intermedia 197. The mechanism by which PDWHF promotes healing remains largely unstudied; however, upregulation of α V β 3 in capilliaries surrounding treated, but not untreated wounds, has been observed 198. Not all studies using PDWHF have demonstrated a positive effect on wound healing compared to placebo 199.…”

Section: Functional Roles Of Platelet α-Granulesmentioning

confidence: 99%

Platelet α-granules: Basic biology and clinical correlates

2009

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Summaryα-Granules are essential to normal platelet activity. These unusual secretory granules derive their cargo from both regulated secretory and endocytotic pathways in megakaryocytes. Rare, inheritable defects of α-granule formation in mice and man have enabled identification of proteins that mediate cargo trafficking and α-granule formation. In platelets, α-granules fuse with the plasma membrane upon activation, releasing their cargo and increasing platelet surface area. The mechanisms that control α-granule membrane fusion have begun to be elucidated at the molecular level. SNAREs and SNARE accessory proteins that control α-granule secretion have been identified. Proteomic studies demonstrate that hundreds of bioactive proteins are released from α-granules. This breadth of proteins implies a versatile functionality. While initially known primarily for their participation in thrombosis and hemostasis, the role of α-granules in inflammation, atherosclerosis, antimicrobial host defense, wound healing, angiogenesis, and malignancy has become increasingly appreciated as the function of platelets in the pathophysiology of these processes has been defined. This review will consider the formation, release, and physiologic roles of α-granules with special emphasis on work performed over the last decade. Keywordsα-granule; vesicle trafficking; endocytosis; secretion; hemostasis Overview of platelet α-granulesPlatelets are anucleate, discoid shaped blood cells that serve a critical function in hemostasis and other aspects of host defense. These cells are replete with secretory granules, which are critical to normal platelet function. Among the three types of platelet secretory granules -α-granules, dense granules, and lysosomes -the α-granule is the most abundant. There are approximately 50-80 α-granules per platelet, ranging in size from 200-500 nm. 1 They comprise roughly 10% of the platelet volume, 10-fold more than dense granules. The total α-granule membrane surface area per platelet is 14 μm 2 , ~8-fold more than dense granules and approximately equal to that of the open canalicular system (OCS), 1 an elaborate system of tunneling invaginations of the cell membrane unique to the platelet. 2 The extra membrane *Address correspondence to: Robert Flaumenhaft, M.D., Ph.D., Center for Life Science, Rm 939, Beth Israel Deaconess Medical Center, 3 Blackfan Circle, Boston, MA, 02215. Tel: 617-735-4005, Fax: 617-735-4000, Email: E-mail: rflaumen@bidmc.harvard.edu. Conflict of interest statementThe authors have no conflicts of interest to declare.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the jour...

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“…Among these, integrin α v β 3 is expressed at low levels on quiescent endothelial cells in vivo, but is significantly elevated during wound angiogenesis, inflammation [16, 17], and tumor angiogenesis [18–20]. Importantly, expression of this integrin served as a basis for elegant tumor imaging studies [21–23].…”

Section: Introductionmentioning

confidence: 99%

Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis

2009

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The cross-talk between receptor tyrosine kinases and integrin receptors are known to be crucial for a number of cellular functions. On endothelial cells, an interaction between integrin α v β 3 and VEGFR2 seems to be particularly important process during vascularization. Importantly, the functional association between VEGFR2 and integrin α v β 3 is of reciprocal nature since each receptor is able to promote activation of its counterpart. This mutually beneficial relationship regulates a number of cellular activities involved in angiogenesis, including endothelial cell migration, survival and tube formation, and hematopoietic cell functions within vasculature. This article discusses several possible mechanisms reported by different labs which mediate formation of the complex between VEGFR-2 and α v β 3 on endothelial cells. The pathological consequences and regulatory events involved in this receptor cross-talk are also presented.

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Autologous platelet-derived wound healing factor promotes angiogenesis via alphavbeta3-integrin expression in chronic wounds.

Cited by 19 publications

References 0 publications

Releasing growth factors from activated human platelets after chitosan stimulation: a possible bio‐material for platelet‐rich plasma preparation

Releasing growth factors from activated human platelets after chitosan stimulation: a possible bio‐material for platelet‐rich plasma preparation

Platelet α-granules: Basic biology and clinical correlates

Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis

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