Autologous platelet concentrates for bone graft enhancement in sinus lift procedure

Abstract

Topical use of APCs might be helpful in bone reconstruction. No clinical, radiologic, or histologic osteogenesis inhibition of high PLT concentration was observed. The resulting osteogenesis was adapted to dental implant placements.

Maxillary sinus lift with solely autogenous bone compared to a combination of autogenous bone and growth factors or (solely) bone substitutes. A systematic review

“…Biopsies taken after 6 and 7 months did not show any statistical difference. By contrast, BETTEGA et al 2 , RAGHOEBAR et al 22 and SCHAAF et al 24 did not observe any significant difference between both treatments, at the 3 and 6 months evaluations. A meta-analysis of the four included articles failed to show a significant effect of PRP, as the calculated pooled difference [95% CI] in bone fraction was À0.398 [À0.796 to À0.001]; (P = 0.341).…”

“…Various authors concluded that no relevant differences in healing of soft tissues and bone existed between sites reconstructed with autogenous bone and autogenous bone mixed with PRP 2,22,24 . Four trials evaluated the possible advantage of using PRP to accelerate bone healing for sinus augmentation 2,5,22,24 . No clinical benefit could be observed in a meta-analysis of these studies when using PRP, in other words there is no scientific support for justifying its use in application.…”

“…The effect of maxillary sinus floor elevation on the survival of endosseous dental implants has been reviewed systematically in general terms in the past 2,14,37 , but a detailed analysis of the efficacy of using an autogenous bone graft compared with bone substitutes and bone growth factors on bone formation and implants was not carried out. The authors of the reviews discussed solely autogenous bone or only bone substitutes, but did not compare the treatment outcome of various grafting materials with autogenous bone serving as a control.…”

Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus

“…• Two-stage lateral sinus lift with autogenous corticocancellous blocks from the iliac crest versus granules of bone with platelet concentrates (APCs) and a biologic glue (Tissucol, Baxter SA, Maurepas, France), left to heal for 6 months in a split-mouth trial (Bettega 2009). Plateletpheresis was made at least 3 days before surgery on a plateletpheresis collection system (Trima Accel, Version 5.1, Gambro BCT, Lakewood, CO), a single-needle continuous-flow separation system.…”

“…• Bone gain expressed in mm or percentage: vertical bone gain was measured in mm by direct measurement in three trials (Schaaf 2008;Bettega 2009;Felice 2009b), however for two trials (Schaaf 2008;Bettega 2009) data were presented in a way we could not use.…”