Autologous periodontal ligament cells in the treatment of class II furcation defects: a study in dogs

Suaid, Fabricia Ferreira; Ribeiro, Fernanda Vieira; Rodrigues, T.; Silvério, Karina Gonzáles; Carvalho, Marcelo Diniz; Nociti, Francisco Humberto; Casati, Márcio Zaffalon; Sallum, Enílson Antônio

doi:10.1111/j.1600-051x.2011.01715.x

Cited by 30 publications

(48 citation statements)

References 32 publications

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“…Supplementation of guided tissue regeneration with periodontal ligament cells for the treatment of class Ⅱ and Ⅲ furcation defects in dogs enhances periodontal regeneration [95,97] . Twelve weeks after PDLSCs with an HA/TCP scaffold were transplanted into periodontal defects in a minipig model, new bone, cementum and periodontal ligament formation was observed [98] .…”

Section: Perspectives On Tdscs In Regenerative Approachesmentioning

confidence: 99%

“…Due to their interesting properties, including self-renewal and differentiation abilities, MSCs are considered important for tissue maintenance and renewal, and, therefore, a promising candidate for tissue engineering [24,[90][91][92][93][94] . Some studies demonstrated that cell-based therapies are able to regenerate dental tissues [48,57,70,[95][96][97][98] . In a study in dogs, complete pulp regeneration was achieved when CD105…”

Section: Perspectives On Tdscs In Regenerative Approachesmentioning

confidence: 99%

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Tooth-derived stem cells: Update and perspectives

Saito¹,

Silvério²,

Casati³

et al. 2015

WJSC

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Section: Perspectives On Tdscs In Regenerative Approachesmentioning

confidence: 99%

Section: Perspectives On Tdscs In Regenerative Approachesmentioning

confidence: 99%

Tooth-derived stem cells: Update and perspectives

Saito¹,

Silvério²,

Casati³

et al. 2015

WJSC

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“…Defect type plays a crucial role in avoiding the epithelium migration and holding the implanted scaffolds in place of defect (Suaid et al 2011). In the study of Caplanis et al, no histological effects on bone activation or regeneration attachment were found following the application of demineralized freezedried bone allografts in maxillary canine defects after 4 weeks.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the bone regeneration in calvarial defect using osteoblasts differentiated from adipose-derived mesenchymal stem cells on three different scaffolds: an animal study

et al. 2015

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The aim of this study was to investigate the effect of three different scaffolds on the viability and differentiation of adipose-derived mesenchymal stem cells (ADMSCs) to osteoblast for bone regeneration of calvarial defect in rabbit model. Adipose was harvested from the nape of 12 rabbits by direct surgery or hollow-tip cannula. Two standardized circular calvarial defects (case and control), 8 mm in diameter each, were created in all the animals. The animals were divided into 3 different groups. In group 1 (G1), the defect was filled with polyamide + ADMSC. In group 2, poly lactic-co-glycolic acid + ADMSC was used. In group 3, decellularized amniotic membrane + ADMSC was applied. In the control defect, the non-seeded scaffolds were applied for filling the defect. Decellularized pericardial scaffolds were used as a membrane on the scaffolds. The animals were euthanized 2, 4, and 8 weeks of operation and new bone formation was assessed by different analyses. Immunohistochemical (IHC) staining with osteopontin and osteocalcin antibodies was also performed. After 2 weeks of wound healing, minimal bone regeneration was detected in all groups. Almost complete defect closure was observed in all experimental groups after 8 weeks of operation, with the greatest defect closure in the animals treated with polyamide scaffolds as compared to biopsies obtained from control defects and other experimental groups. The maximal tensile load was higher in G1, 4 and 8 weeks postoperatively, suggesting the usefulness of polyamide + ADMSC for bone regeneration in calvarial defects. Results of the IHC staining demonstrated a significant difference between seeded and non-seeded scaffold in both short- and long-term follow-ups (P < 0.05). In addition, a significant difference was observed in enhancement of IHC staining of both markers in polyamide group (seeded or non-seeded) 4 and 8 weeks postoperatively in comparison with other scaffolds. It was concluded that bone regeneration in critical calvarial defect was more successful in seeded polyamide.

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“…Increasing amount of research presents TDSCs applicability in diverse conditions, including myocardial infarction 36 , ischemic disease 37 42 , hair follicle loss 43 , skin injuries 44 , salivary gland defects 45 , corneal reproduction 46 , and the regeneration of dental tissues 12,22,35,[47][48][49] . Several studies demonstrated that TDSCs have successfully regenerated dental tissues such as dentin, pulp and periodontal ligament 12,22,[47][48][49] .…”

Section: Regenerative Applications Of Tdscsmentioning

confidence: 99%

“…Several studies demonstrated that TDSCs have successfully regenerated dental tissues such as dentin, pulp and periodontal ligament 12,22,[47][48][49] . In vivo experiments demonstrated that human PDLSCs and SCAP were able to generate periodontal ligament in minipigs 22 .…”

Section: Regenerative Applications Of Tdscsmentioning

confidence: 99%