Autologous osteochondral transplantation for the treatment of chondral defects of the knee

Karataglis, Dimitrios; Green, M.A.; Learmonth, D.J.A.

doi:10.1016/j.knee.2005.05.006

Cited by 64 publications

(44 citation statements)

References 26 publications

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“…The model was subsequently served to investigate the effect of several common osteochondral defects (i.e., localized bone fracture, cartilage split, loss of vertical fibrils and bone boss) on biomechanics of the joint under up to 1500 or 2000 N compression at the transient period (i.e., under physiological loading rates). For comparison purposes and in accordance with reported defect sizes (Henderson and La Valette, 2005;Karataglis et al, 2006), a local area of 116 mm 2 (15% of total lateral surface) at the loaded region of the lateral compartment was chosen for lesion simulations. Moreover for the current study under compression, only the lateral compartment of the knee joint was modelled neglecting the medial compartment and joint ligaments.…”

Section: Discussionmentioning

confidence: 99%

“…To examine the effect of tibial bone fracture and in accordance with the literature on the size of defects (Henderson and La Valette, 2005;Karataglis et al, 2006), a local region of the tibial bone as well as its calcified cartilage under the loaded area of the cartilage (i.e., 15% or 116 mm 2 of the lateral compartmental surface and to 7.1 mm depth, Fig. 1) was weakened by reducing its elastic modulus either to E ¼ 20 MPa (case b) or further to E ¼ 5 MPa (case c) with Poisson's ratio of 0.0 in both cases.…”

Section: Cases Studiedmentioning

confidence: 99%

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Computational biomechanics of articular cartilage of human knee joint: Effect of osteochondral defects

Shirazi

Shirazi‐Adl

2009

Journal of Biomechanics

107

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Section: Discussionmentioning

confidence: 99%

Section: Cases Studiedmentioning

confidence: 99%

Computational biomechanics of articular cartilage of human knee joint: Effect of osteochondral defects

Shirazi

Shirazi‐Adl

2009

Journal of Biomechanics

107

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“…These vary from nonsurgical treatments, such as protected weightbearing, to subchondral drilling of the defect, fragment fixation, fragment excision, arthroplasty, or the use of an osteochondral autograft or allograft [1,5,6,13].…”

Section: Discussionmentioning

confidence: 99%

Case Report: Osteochondritis Dissecans in Twins

Mackie

Wilkins

2010

Clinical Orthopaedics &Amp; Related Research

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Osteochondritis dissecans is a lesion of subchondral bone with subsequent involvement of the overlying cartilage. Although the etiology of the disease is unknown, mechanical, traumatic, and ischemic etiologies have been suggested, in addition to developmental and genetic factors. There are several treatment options depending on the stage of the disease and surgeon preference. The use of a fresh osteochondral allograft for treatment of a lesion of the femoral condyle is relatively new, and we report its use in a unique situation involving identical twins who both presented with osteochondritis dissecans of the same anatomic location within 2 years of each other. Since these were identical lesions in identical twins, this commonality supports the suggestion that some genetic component may be present in the etiology, especially in this situation where a genetic connection existed. We recommend genetic studies to determine the extent of genetic influence on the disease.

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“…All the defects were simulated on the medial femoral cartilage, which corresponded to the most often damaged condyle [15] . According to the obtained healthy knee FEA results, two locations of low and high loadbearing areas of the medial femoral cartilage were defined.…”

Section: Fea Of Cartilage Defectsmentioning

confidence: 99%

Accurate 3D reconstruction of subject-specific knee finite element model to simulate the articular cartilage defects

Zhang

et al. 2011

J. Shanghai Jiaotong Univ. (Sci.)

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The biomechanical relationship between the articular cartilage defect and knee osteoarthritis (OA) has not been clearly defined. This study presents a 3D knee finite element model (FEM) to determine the effect of cartilage defects on the stress distribution around the defect rim. The complete knee FEM, which includes bones, articular cartilages, menisci and ligaments, is developed from computed tomography and magnetic resonance images. This FEM then is validated and used to simulate femoral cartilage defects. Based on the obtained results, it is confirmed that the 3D knee FEM is reconstructed with high-fidelity level and can faithfully predict the knee contact behavior. Cartilage defects drastically affect the stress distribution on articular cartilages. When the defect size was smaller than 1.00 cm 2 , the stress elevation and redistribution were found undistinguishable. However, significant stress elevation and redistribution were detected due to the large defect sizes ( 1.00 cm 2 ). This alteration of stress distribution has important implications relating to the progression of cartilage defect to OA in the human knee joint.

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Autologous osteochondral transplantation for the treatment of chondral defects of the knee

Cited by 64 publications

References 26 publications

Computational biomechanics of articular cartilage of human knee joint: Effect of osteochondral defects

Computational biomechanics of articular cartilage of human knee joint: Effect of osteochondral defects

Case Report: Osteochondritis Dissecans in Twins

Accurate 3D reconstruction of subject-specific knee finite element model to simulate the articular cartilage defects

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