Accurate 3D reconstruction of subject-specific knee finite element model to simulate the articular cartilage defects

Hu, Guanghong; Zhang, Luo-lian; Hu, Yang; Dong, Yuefu; Xu, Qiu

doi:10.1007/s12204-011-1199-z

Cited by 13 publications

(13 citation statements)

References 25 publications

(38 reference statements)

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“…Consequently, the effect of volumetric loss of tissue and geometrical changes of the articular surface as clinically present with cartilage defects on the load distribution were neglected. Nonetheless, the changes in contact pressure distribution after defect creation were consistent with finite element studies incorporating more geometrical detail and different material models [ 41 – 44 , 78 ]. Our use of an elastic foundation contact model enabled the use of complex geometries whilst simulating large range of motion under physiological loading conditions and realistic movement pattern.…”

Section: Discussionsupporting

confidence: 75%

Cartilage defect location and stiffness predispose the tibiofemoral joint to aberrant loading conditions during stance phase of gait

Zevenbergen¹,

Cr²,

Rossom³

et al. 2018

PLoS ONE

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ObjectivesThe current study quantified the influence of cartilage defect location on the tibiofemoral load distribution during gait. Furthermore, changes in local mechanical stiffness representative for matrix damage or bone ingrowth were investigated. This may provide insights in the mechanical factors contributing to cartilage degeneration in the presence of an articular cartilage defect.MethodsThe load distribution following cartilage defects was calculated using a musculoskeletal model that included tibiofemoral and patellofemoral joints with 6 degrees-of-freedom. Circular cartilage defects of 100 mm2 were created at different locations in the tibiofemoral contact geometry. By assigning different mechanical properties to these defect locations, softening and hardening of the tissue were evaluated.ResultsResults indicate that cartilage defects located at the load-bearing area only affect the load distribution of the involved compartment. Cartilage defects in the central part of the tibia plateau and anterior-central part of the medial femoral condyle present the largest influence on load distribution. Softening at the defect location results in overloading, i.e., increased contact pressure and compressive strains, of the surrounding tissue. In contrast, inside the defect, the contact pressure decreases and the compressive strain increases. Hardening at the defect location presents the opposite results in load distribution compared to softening. Sensitivity analysis reveals that the surrounding contact pressure, contact force and compressive strain alter significantly when the elastic modulus is below 7 MPa or above 18 MPa.ConclusionAlterations in local mechanical behavior within the high load bearing area resulted in aberrant loading conditions, thereby potentially affecting the homeostatic balance not only at the defect but also at the tissue surrounding and opposing the defect. Especially, cartilage softening predisposes the tissue to loads that may contribute to accelerated risk of cartilage degeneration and the initiation or progression towards osteoarthritis of the whole compartment.

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Section: Discussionsupporting

confidence: 75%

Cartilage defect location and stiffness predispose the tibiofemoral joint to aberrant loading conditions during stance phase of gait

Zevenbergen¹,

Cr²,

Rossom³

et al. 2018

PLoS ONE

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“…Moreover, the results for cartilage-bone interface damage indicated increased chance of OA onset and progression [198]. A subject-specific study on the size effect of cartilage defect indicated a size threshold of 1.0 cm 2 at which considerable change in cartilage stresses would occur around the defect rim [199]. …”

Section: Pathomechanical Modeling and Clinical Applicationsmentioning

confidence: 99%

Recent Advances in Computational Mechanics of the Human Knee Joint

Kazemi

Dabiri

2013

Computational and Mathematical Methods in Medicine

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Computational mechanics has been advanced in every area of orthopedic biomechanics. The objective of this paper is to provide a general review of the computational models used in the analysis of the mechanical function of the knee joint in different loading and pathological conditions. Major review articles published in related areas are summarized first. The constitutive models for soft tissues of the knee are briefly discussed to facilitate understanding the joint modeling. A detailed review of the tibiofemoral joint models is presented thereafter. The geometry reconstruction procedures as well as some critical issues in finite element modeling are also discussed. Computational modeling can be a reliable and effective method for the study of mechanical behavior of the knee joint, if the model is constructed correctly. Single-phase material models have been used to predict the instantaneous load response for the healthy knees and repaired joints, such as total and partial meniscectomies, ACL and PCL reconstructions, and joint replacements. Recently, poromechanical models accounting for fluid pressurization in soft tissues have been proposed to study the viscoelastic response of the healthy and impaired knee joints. While the constitutive modeling has been considerably advanced at the tissue level, many challenges still exist in applying a good material model to three-dimensional joint simulations. A complete model validation at the joint level seems impossible presently, because only simple data can be obtained experimentally. Therefore, model validation may be concentrated on the constitutive laws using multiple mechanical tests of the tissues. Extensive model verifications at the joint level are still crucial for the accuracy of the modeling.

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“…An articular cartilage defect (ACD) in the knee changes the mechanical properties of the remaining cartilage. The presence of the ACD is known to increase the stress in the remaining healthy cartilage 2e5 and reduces the ability of the surrounding tissue to withstand compressive and shear forces, rendering the remaining cartilage vulnerable to degeneration from mechanical loading 3,4,6 . With walking, knees are subjected to millions of loading cycles throughout a lifetime, thus the manner in which people load the knee during gait could either exacerbate or reduce stresses in the remaining cartilage.…”

Section: Introductionmentioning

confidence: 99%

Differential knee joint loading patterns during gait for individuals with tibiofemoral and patellofemoral articular cartilage defects in the knee

Thoma

McNally

Chaudhari

et al. 2017

Osteoarthritis and Cartilage

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Accurate 3D reconstruction of subject-specific knee finite element model to simulate the articular cartilage defects

Cited by 13 publications

References 25 publications

Cartilage defect location and stiffness predispose the tibiofemoral joint to aberrant loading conditions during stance phase of gait

Cartilage defect location and stiffness predispose the tibiofemoral joint to aberrant loading conditions during stance phase of gait

Recent Advances in Computational Mechanics of the Human Knee Joint

Differential knee joint loading patterns during gait for individuals with tibiofemoral and patellofemoral articular cartilage defects in the knee

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