Autologous mesenchymal stem cells application in post-burn scars treatment: a preliminary study

Zahorec, Peter; Sarkozyova, Nina; Ferancikova, Nikola; Bukovčan, Peter; Danišovič, Ľuboš; Boháč, Martin; Tomáš, Miroslav; Koller, Ján

doi:10.1007/s10561-020-09862-z

Cited by 10 publications

(10 citation statements)

References 23 publications

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“…33 They stimulate fibroblast to secrete collagen I, II, III, and V, oxylatan, and elastin using pathways like Wnt/β-catenin, or PI3K/Akt. 34,35 ADSCs secrete interleukin-6 (IL-6), glutathione peroxidase (GPx), SOD, and catalase to upregulate antioxidant response, as well as inhibit secretion of myeloperoxidase (MPO) and reduce oxidative stress. 36,37 SVs have a potential protective effect against the development of fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Combined therapies in scar treatment—The role of autologous derived agents in scar remodeling: A series of cases

Surowiecka

2022

Dermatologic Therapy

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Comprehensive scar treatment usually requires a combination of several methods.The selection of methods should depend on the appearance and biology of the scar.The aim of this study was to determine the safety and efficiency of combined methods with the use of autologous derived agents in the treatment of scars, based on the available literature and own experience. The study consists of a description of three cases treated with autologous derived agents: platelet-rich plasma (PRP), lipofilling or stromal vascular fraction (SVF) in combination with radiofrequency, CO 2 laser, or cutting threads. No adverse events were reported. Improvement in scar quality and function was observed in all cases. Combination of autologous derived injectables with medical devices is safe and accelerates both cosmetic and functional results.

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Section: Discussionmentioning

confidence: 99%

Combined therapies in scar treatment—The role of autologous derived agents in scar remodeling: A series of cases

Surowiecka

2022

Dermatologic Therapy

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“…Zahorec et al described a case of post-burn hypertrophic scars corrected with surgical excision followed by lipofilling and injections of autologous isolated and cultured ADSCs. The obtained improvement in scar quality showed a reduction in Vancouver Scar Score (VSS) from 7.63 points to 2.38 at the 6-month follow-up [ 80 ].…”

Section: Methodsmentioning

confidence: 99%

Mesenchymal Stem Cells in Burn Wound Management

Surowiecka

Chrapusta²,

Klimeczek-Chrapusta³

et al. 2022

IJMS

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Mesenchymal stem cells have a known regenerative potential and are used in many indications. They secrete many growth factors, including for fibroblasts (FGF), endothelium (VEGF), as well as 14 anti-inflammatory cytokines, and they stimulate tissue regeneration, promoting the secretion of proteins and glycosaminoglycans of extracellular matrices, such as collagen I, II, III, and V, elastin, and also metalloproteinases. They secrete exosomes that contain proteins, nucleic acids, lipids, and enzymes. In addition, they show the activity of inactivating free radicals. The aim of this study was an attempt to collect the existing literature on the use of stem cells in the treatment of a burn wound. There were 81 studies included in the analysis. The studies differed in terms of the design, burn wound model, source of stem cells, and methods of cellular therapy application. No major side effects were reported, and cellular therapy reduced the healing time of the burn wound. Few case reports on human models did not report any serious adverse events. However, due to the heterogeneity of the evidence, cellular therapy in burn wound treatment remains an experimental method.

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“…Moreover, they are more in line with people's ethical requirements and are recognized by more people. At present, autologous MSCs have been used to treat several diseases, including multiple sclerosis (40), post-burn scar treatment (41), refractory rectovaginal Crohn's fistulas (42), and patients with advanced tumors (43), among others (Table 2). In addition, MSCs can be classified by source, as either dental pulp MSCs (44), human umbilical cord MSCs (45), bone marrow MSCs (46), and adipose tissue-derived MSCs (47).…”

Section: Types Of Mesenchymal Stem Cellsmentioning

confidence: 99%

“…Moreover, they are more in line with people’s ethical requirements and are recognized by more people. At present, autologous MSCs have been used to treat several diseases, including multiple sclerosis ( 40 ), post-burn scar treatment ( 41 ), refractory rectovaginal Crohn’s fistulas ( 42 ), and patients with advanced tumors ( 43 ), among others ( Table 2 ).…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

The Latest Developments in Immunomodulation of Mesenchymal Stem Cells in the Treatment of Intrauterine Adhesions, Both Allogeneic and Autologous

et al. 2021

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Intrauterine adhesion (IUA) is an endometrial fibrosis disease caused by repeated operations of the uterus and is a common cause of female infertility. In recent years, treatment using mesenchymal stem cells (MSCs) has been proposed by many researchers and is now widely used in clinics because of the low immunogenicity of MSCs. It is believed that allogeneic MSCs can be used to treat IUA because MSCs express only low levels of MHC class I molecules and no MHC class II or co-stimulatory molecules. However, many scholars still believe that the use of allogeneic MSCs to treat IUA may lead to immune rejection. Compared with allogeneic MSCs, autologous MSCs are safer, more ethical, and can better adapt to the body. Here, we review recently published articles on the immunomodulation of allogeneic and autologous MSCs in IUA therapy, with the aim of proving that the use of autologous MSCs can reduce the possibility of immune rejection in the treatment of IUAs.

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Autologous mesenchymal stem cells application in post-burn scars treatment: a preliminary study

Cited by 10 publications

References 23 publications

Combined therapies in scar treatment—The role of autologous derived agents in scar remodeling: A series of cases

Combined therapies in scar treatment—The role of autologous derived agents in scar remodeling: A series of cases

Mesenchymal Stem Cells in Burn Wound Management

The Latest Developments in Immunomodulation of Mesenchymal Stem Cells in the Treatment of Intrauterine Adhesions, Both Allogeneic and Autologous

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