Autologous Fibrinogen for Tissue-Adhesion, Hemostasis and Embolization

Gestring, G. F.; Lerner, Robert G.

doi:10.1177/153857448301700504

Cited by 54 publications

(18 citation statements)

References 5 publications

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“…The 'Rat Skin Test' [2] measures the adhe sive properties of two round rat skin patches setup similar to ours. The measured adhesive strength was between l and 2 N/cm2, much higher than what we observed.…”

Section: Discussionmentioning

confidence: 99%

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Liver surgery Measuring the Rupture Stress Point of Biological Sealant-Collagen Bonding: Validation of a Technique Used after Hepatectomy

et al. 1993

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The aim of this experimental study was to measure the rupture stress point of a fibrin clot situated on a liver, in realistic surgical conditions. The experimental method was carried out with a machined wooden cylinder bonded on the liver, connected with a wire to a setup and pulled at a constant speed, and a sensor was placed on the wire measuring the applied strength. This method, realized in the dog, made it possible to validate a precise and reproducible method designed for testing the adhesive characteristics of biological sealant-collagen bonding on the liver.

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Section: Discussionmentioning

confidence: 99%

“…Experimental measure ment of this adhesive strength seems to be necessary to compare the effectiveness of dif ferent products. The 'Rat Skin Test' devel oped by Gesting and Lerner [2] aim of this study was to validate a method designed to test the adhesive characteristics of the fibrin clot in realistic surgical conditions.…”

Section: Introductionmentioning

confidence: 99%

Liver surgery Measuring the Rupture Stress Point of Biological Sealant-Collagen Bonding: Validation of a Technique Used after Hepatectomy

et al. 1993

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“…Inlay shows detail of the GraftConnector  stent sutures remained permanently. Gestring et al 64,65 were the first to use fibrin glue for end-to-side vascular anastomoses in dogs and rabbits. They used a sutureless technique in which the angled end of the femoral artery was pulled into the femoral vein.…”

Section: Adhesivesmentioning

confidence: 99%

Non-suture methods of vascular anastomosis

Zeebregts¹,

Dungen³

et al. 2003

British Journal of Surgery

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The non-suture techniques can be categorized into five groups based on the materials used: rings, clips, adhesives, stents and laser welding. With all these techniques a faster and less traumatic anastomosis can be made compared with sutures. However, each device is associated with technique-related complications. As a consequence, suturing continues to be the standard approach. The disadvantages of the non-suture techniques include: rigidity and a non-compliant anastomosis with rings; toxicity, leakage and aneurysm formation with adhesives; early occlusion with stents; cost, reduced strength in larger-sized vessels and demand for surgical skills with laser welding. Further refinement is needed before widespread adoption of these techniques can occur. Clips, however, may be particularly promising but long-term evaluation is required.

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“…Many investigators suggest that reduced suture FG vascular anastomoses reduce the risk of these complications [24,61,85,[95][96][97][98][99][100][101][102][103][104]. Reduced suture vascular anastomosis can also be performed by less experienced surgeons in signi cantly shorter time [7,24,97,103,105].…”

Section: Reduced Suture Fibrin Glue Anastomosesmentioning

confidence: 99%

Sutureless and Reduced Suture Anastomosis of Hollow Vessels With Fibrin Glue: A Review

Detweiler

Fenton

1999

Journal of Investigative Surgery

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Research in reduced suture fibrin glue (FG) and sutureless FG anastomosis has been lagging behind FG utilization in other surgical fields. A review of the literature for vascular, esophageal, tracheal, gastrointestinal, common bile duct, ureteral, vas deferens, and Fallopian tube FG anastomosis indicates that reduced suture FG and sutureless FG procedures may be performed with less training, reduced operating time, leakage, ischemia, inflammation, and necrosis compared to sutured techniques. Reduced suture FG vascular anastomosis augments early anastomotic strength. Suture number for esophageal, tracheal, and tracheobronchial anastomoses can be reduced with FG. Bursting strength in pig small intestine and rat colon was lower at 4 days postoperatively, but returned to sutured strength at 7 days. Mortality was unaffected, and 18-month follow-up in sutureless FG intestinal anastomosis in pigs showed no stenosis. Preliminary ureteral studies have demonstrated successful sutureless FG and reduced suture FG laparoscopic techniques in pigs. Reduced suture FG and sutureless FG vas deferens anastomosis may reduce sperm granuloma rates, with increased patency and pregnancy rates. Patency and pregnancy rates have been similar for tubal FG, reduced suture FG, autologous fibrin glue (AFG), and sutured anastomosis. Any risk of viral transmission or immune response is eliminated by AFG. While there are few studies in many areas of FG hollow vessel anastomosis, the current literature illustrates many of the advantages of FG over other anastomotic techniques and should provide impetus for continued research in this promising field of surgery.

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Autologous Fibrinogen for Tissue-Adhesion, Hemostasis and Embolization

Cited by 54 publications

References 5 publications

Liver surgery Measuring the Rupture Stress Point of Biological Sealant-Collagen Bonding: Validation of a Technique Used after Hepatectomy

Liver surgery Measuring the Rupture Stress Point of Biological Sealant-Collagen Bonding: Validation of a Technique Used after Hepatectomy

Non-suture methods of vascular anastomosis

Sutureless and Reduced Suture Anastomosis of Hollow Vessels With Fibrin Glue: A Review

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