Autologous Fat Transplantation

Pinski, Kevin S.; Roenigk, Henry H.

doi:10.1111/j.1524-4725.1992.tb02795.x

Cited by 186 publications

(107 citation statements)

References 24 publications

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“…However, complications such as fat reabsorption and necrosis still remain an issue occurring with a rate of 30% to 70% (11,12). Due to their inherent properties, ASCs have recently attracted an increased interest (13).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Viability and Yield of Adipose-Derived Stem Cells (ASCs) from Different Donor Areas

Tsekouras

Mantas

Tsilimigras

et al. 2017

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Over the last few years, autologous fat grafting has been at the forefront of aesthetic plastic surgery clinical practice, since it provides exceptional results for the treatment of soft-tissue contour deformities (1, 2). Similar to bone marrow, the adipose tissue is derived from the embryonic mesenchyme and contains a supportive stromal vascular fraction (SVF) that can be easily isolated (3). Typically, SVF from adipose tissue contains different types of cells, including endothelial cells, smooth muscle cells, pericytes, leukocytes and pre-adipocytes, otherwise named as adipose-derived stem cells (ASCs) (4).The potential of ASCs to differentiate into diverse cell types both in vitro and in vivo, offers outstanding opportunities for their clinical application as therapeutic agents (5). In particular, preclinical studies have revealed their capacity to differentiate toward the osteogenic, adipogenic, myogenic, and chondrogenic lineages (6, 7). Nevertheless, adipose tissue displays a significant heterogeneity in terms of stem cell yield, proliferation, and differentiation capacity not only among individuals, but even when comparing different fat depots within one individual (8). 1229This article is freely accessible online.Correspondence to: Diamantis I. Tsilimigras, MD,

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Section: Discussionmentioning

confidence: 99%

Comparison of the Viability and Yield of Adipose-Derived Stem Cells (ASCs) from Different Donor Areas

Tsekouras

Mantas

Tsilimigras

et al. 2017

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“…Most of the surgeons use the proceeded material immediately after fat grafting but in literature could be found examples for graft freezing and subsequent use (Coleman WP 1999;Fulton et al, 1998;Bertossi et al, 2000) or graft enrichment with growth factors and other substances increasing the chances of graft survival (Pinski et al, 1992;Scholler et al, 2001).…”

Section: Reimplantationmentioning

confidence: 99%

Autologous Fat Grafting - Factors of Influence on the Therapeutic Results

Khater¹,

Atanassova²

2012

Current Concepts in Plastic Surgery

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“…The published survival rates of FAG are divergent, ranging from 10 to 90% (Matsudo and Toledo, 1988;Nguyen et al, 1990;Pinski and Roenigk, 1992). The following questions remain unanswered (Goldwyn, 1988): Does the fat graft survive on the face?…”

Section: Introductionmentioning

confidence: 99%

First Use of Stereology to Quantify the Survival of Fat Autografts

Cuellar¹,

Solís²

2011

Image Anal Stereol

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It is not usual to perform quantitative analyses on surgical materials. Rather, they are evaluated clinically, through qualitative methods, and if quantitation is done, it is on a 2-dimensional basis. In this study, the long-term survival of fat autografts (FAG) in 40 subjects with facial soft tissue defects is quantified. An adipose tissue preparation from the abdomen obtained through liposuction and centrifugation is injected subcutaneously. Approximately 14 months later, the treated area is biopsied. Extensive computer-based histological analyses were performed using the stereological method in order to directly obtain three parameters: volume fraction of adipocytes in the fat tissue (V V ), density (number per volume) of adipocytes in the fat tissue (N V ), and the mean cell volume of adipocytes (VA) in each tissue sample. A set of equations based on these three quantitative parameters is produced for evaluation of the volumetric survival fraction (VSF) of FAG. The presented data evidenced a 66% survival fraction at the 14-month follow-up. In routine practice, it would be sufficient to perform this volumetric analysis on the injected and biopsied fat samples to know what fraction of the FAG has survived. This is an objective method for quantifying FAG survival and will allow a standardized comparison between different research series and authors.

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Autologous Fat Transplantation

Cited by 186 publications

References 24 publications

Comparison of the Viability and Yield of Adipose-Derived Stem Cells (ASCs) from Different Donor Areas

Comparison of the Viability and Yield of Adipose-Derived Stem Cells (ASCs) from Different Donor Areas

Autologous Fat Grafting - Factors of Influence on the Therapeutic Results

First Use of Stereology to Quantify the Survival of Fat Autografts

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