Autologous Fat Grafting and Facial Reconstruction

Wetterau, Meredith; Szpalski, Caroline; Hazen, Alexes; Warren, Stephen M.

doi:10.1097/scs.0b013e318241e1de

Cited by 68 publications

(40 citation statements)

References 39 publications

(31 reference statements)

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“…Jahrhundert statt [23]. Die Wirksamkeit und Sicherheit von Fettinjektionen ist im Bereich der Hals-Nasen-Ohren-Heilkunde sowohl bei Fettaugmentationen der Stimmlippen [24] als auch bei Eingriffen der plastischen Gesichtschirurgie [25,26] seit mehr als 20 Jahren dokumentiert worden. Adipogene Stammzellen werden seit mehreren Jahren als regeneratives Substrat bei Wundheilungsstörungen eingesetzt [27].…”

Section: Rolle Adipogener Stammzellenunclassified

Potenzial adipogener Stammzellen bei radiogenen Wundheilungsstörungen

Haubner

Gassner

2015

HNO

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Section: Rolle Adipogener Stammzellenunclassified

Potenzial adipogener Stammzellen bei radiogenen Wundheilungsstörungen

Haubner

Gassner

2015

HNO

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“…Despite its proven efficacy as a contouring tool in both reconstructive and cosmetic surgical procedures, fat grafting remains a relatively unpredictable technique (1). Reported graft retention rates vary from 10–90% (1–3).…”

Section: Introductionmentioning

confidence: 99%

Studies in Fat Grafting

Paik

Zielins

Atashroo

et al. 2015

Plastic and Reconstructive Surgery

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Background Cell-assisted lipotransfer has shown much promise as a technique to improve fat graft take. However, the concentration of stromal vascular fraction cells required to optimally enhance fat graft retention remains unknown. Methods Human lipoaspirate was processed for both fat transfer and harvest of stromal vascular fraction (SVF) cells. Cells were then mixed back with fat at varying concentrations ranging from 10,000 to 10 million cells per 200 µl of fat. Fat graft volume retention was assessed via CT scanning over 8 weeks, and then fat grafts were explanted and compared histologically for overall architecture and vascularity. Results Maximum fat graft retention was seen at a concentration of 10,000 cells per 200 µl of fat. The addition of higher number of cells negatively impacted fat graft retention, with supplementation of 10 million cells producing the lowest final volumes, lower than fat alone. Interestingly, fat grafts supplemented with 10,000 cells showed significantly increased vascularity and decreased inflammation, while fat grafts supplemented with 10 million cells showed significant lipodegeneration compared to fat alone Conclusions Our study demonstrates dose dependence in the number of SVF cells that can be added to a fat graft to enhance retention. While cell-assisted lipotransfer may help promote graft survival, this effect may need to be balanced with the increased metabolic load of added cells that may compete with adipocytes for nutrients during the post-graft period.

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“…14 It is commonly suggested to overcorrect the augmentation sites; however, it is often unacceptable for some patients. 15 Several materials are useful for special surgical procedures, such as the superficial musculoaponeurotic system graft during a facelift, or deep temporalis fascia for a forehead and brow lift.…”

Section: Discussionmentioning

confidence: 99%