Autologous Cultured Fibroblast Injection for Facial Contour Deformities: A Prospective, Placebo-Controlled, Phase III Clinical Trial

“…Bu çalışma sonunda toplam hasta memnuniyeti ilk yıl %92 iken 3.-4. yıllarda %70 oranında saptanmıştır. Son yıllarda yapılan bir araştırmada ise OKF ile tedavi edilen hastaların skarlarında 9. ve 12. aylarda %75 ve %81 oranında düzelme saptanmış ve bunun en az 12 ay devam ettiği belirlenmiştir 10 . Watson ve ark'ları akne skarı bulunan 10 hastada OKF tedavisi ile 6. ay sonunda %60-100 arasında gelişme saptamışlar ve skar yüzeyinde %10-85 arasında küçülme belirlemişlerdir 11 .…”

Section: Discussionunclassified

Akne Skarları Tedavisinde Otolog Kültüre Fibroblast Enjeksiyonu

...

2012

Turkderm

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ÖzetAmaç: Yüzde oluşan akne skarları bugün hala önemli bir kozmetik problemdir. Biz bu çalışmada intradermal otolog fibroblast injeksiyonunun akne skarlarındaki tedavi etkinliği ve güvenirliliğini saptamayı amaçladık. Gereç ve Yöntemler: Bu çalışma açık, prospektif, Faz 3 aşamalı bir pilot çalışmadır. Yaşları 21-35 arasında değişen akne skarı olan 6 hasta (4 Erkek, 2 kadın) bu çalışmaya alınmıştır. Otolog fibroblastlar iki doz halinde 20 milyon/ml olarak 2 hafta arayla uygulanmıştır. Hastalar ilk injeksiyondan sonraki 2, 4, 6, ve 12. aylarda değerlendirilmişlerdir. Subjektif değişme skorları her vizitte hasta ve doktor tarafından değerlendirilerek kaydedilmiştir. Sum maryBackground and Design: Acne scars on the face are still an important cosmetic problem. In this study, we aimed to determine the efficacy and safety of intradermal injections of autologous fibroblasts for the treatment of acne scars. Materials and Methods:This was an open, prospective, phase 3, pilot study. Six adults with acne scars (4 male, 2 female; age range: 21-35 years) were included in this study. Autologous cultured fibroblasts (20 million/ml) were given as two doses administered with two weeks interval. Efficacy evaluation was performed 2, 4, 6, and 12 months after the first injections. Subjective improvement scores were noted by patient and clinicians at every follow-up visit. Results: An improvement in acne scars of more than 50% was observed in two of the 6 at 6 months while five of the 6 patients and clinicians also noted 50% to 75% improvement with the treatment at 12 months. The best results were obtained at 12 months. No serious side effects were detected. Conclusion: In this pilot study, intradermal injections of autologous fibroblast were found to be effective and safe for acne scars. (Turk derm 2012; 46: 90-3)

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“…Autologous human dermal fibroblasts obtained from behind the ear have been used to treat facial contour defects in a phase III clinical trial (Isolagen Inc, reorganized in 2009 to Fibrocell Science, Exton, PA, USA) (143). It was observed that autologous dermal fibroblasts were safe and produced improvement especially in the treatment of acne scars.…”

Section: Oral Autologous Grafts For Extra-oral Applicationsmentioning

confidence: 98%

Distinct phenotype and therapeutic potential of gingival fibroblasts

2014

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Autologous Cultured Fibroblast Injection for Facial Contour Deformities: A Prospective, Placebo-Controlled, Phase III Clinical Trial

Abstract: Our results indicate that autologous fibroblast injections can safely and effectively produce improvements in rhytids, acne scars, and other dermal defects continuing for at least 12 months after injection.

Cited by 54 publications

References 31 publications

In Vivo Comparison of Biomimetic Approaches for Tissue Regeneration of the Scarred Vocal Fold

In Vivo Comparison of Biomimetic Approaches for Tissue Regeneration of the Scarred Vocal Fold

Akne Skarları Tedavisinde Otolog Kültüre Fibroblast Enjeksiyonu

Distinct phenotype and therapeutic potential of gingival fibroblasts

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