Autologous Chondrocyte Implantation Versus Microfracture in the Knee: A Meta-analysis and Systematic Review

Gou, Guo-Hau; Tseng, Feng-Jen; Wang, Shenghao; Chen, Pao-Ju; Shyu, Jia‐Fwu; Weng, Ching‐Feng; Pan, Ru-Yu

doi:10.1016/j.arthro.2019.06.033

Cited by 49 publications

(36 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this reason, in this work QOL was monitored along the study. As other authors have found in patients with unilateral defects (23)(24)(25), patients with bilateral cartilage defects treated with autologous chondrocyte implantation had a significant QOL improvement two years after surgery.…”

Section: Location Of Bilateral Chondral Lesions Of Patients Included In This Work Is Depicted Insupporting

confidence: 73%

High-Density Autologous Chondrocyte Implantation (HD-ACI) in patients with bilateral knee chondral defects

Guillén-Vicente

López‐Alcorocho

Rodríguez‐Iñigo

et al. 2021

Journal of Cartilage & Joint Preservation

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Location Of Bilateral Chondral Lesions Of Patients Included In This Work Is Depicted Insupporting

confidence: 73%

High-Density Autologous Chondrocyte Implantation (HD-ACI) in patients with bilateral knee chondral defects

Guillén-Vicente

López‐Alcorocho

Rodríguez‐Iñigo

et al. 2021

Journal of Cartilage & Joint Preservation

View full text Add to dashboard Cite

show abstract

“…46 In a recent meta-analysis of randomized controlled trials, Gou et al found a significant benefit in activities of daily living, quality of life, and pain relief after ACI compared with microfracture. 47 However, they found no difference in the International Knee Documentation Committee (IKDC), Lysholm, or overall KOOS between ACI and microfracture. Ebert et al demonstrated high rates of patient satisfaction and improved clinical and radiographic results for isolated tibiofemoral chondral lesions at 5 years after arthroscopic MACI.…”

Section: Discussionmentioning

confidence: 95%

Management of Large Focal Chondral and Osteochondral Defects in the Knee

et al. 2020

View full text Add to dashboard Cite

Large, focal articular cartilage defects of the knee (> 4 cm2) can be a source of significant morbidity and often require surgical intervention. Patient- and lesion-specific factors must be identified when evaluating a patient with an articular cartilage defect. In the management of large cartilage defects, the two classically utilized cartilage restoration procedures are osteochondral allograft (OCA) transplantation and cell therapy, or autologous chondrocyte implantation (ACI). Alternative techniques that are available or currently in clinical trials include a hyaluronan-based scaffold plus bone marrow aspirate concentrate, a third-generation autologous chondrocyte implant, and an aragonite-based scaffold. In this review, we will focus on OCA and ACI as the mainstay in management of large chondral and osteochondral defects of the knee. We will discuss the techniques and associated clinical outcomes for each, while including a brief mention of alternative treatments. Overall, cartilage restoration techniques have yielded favorable clinical outcomes and can be successfully employed to treat these challenging large focal lesions.

show abstract

“…The primary limitations associated with MSP and MSPþ techniques involve the size and type of defects that can be effectively treated, the potential sequelae to violation of the subchondral bone plate and dependency on bone marrow-derived cells for repair tissue formation, and the durability of the repair tissue and associated progression of pathology to early-onset knee OA. 5,69,75,[86][87][88][89] In addition, MSP has been associated with inferior results for subsequent revision cartilage repair or restoration techniques. [90][91][92] Autologous Chondrocyte Implantation and Matrix-Induced Autologous Chondrocyte Implantation…”

Section: Marrow Stimulation Proceduresmentioning

confidence: 99%

Clinical Application of the Basic Science of Articular Cartilage Pathology and Treatment

et al. 2020

View full text Add to dashboard Cite

The joint is an organ with each tissue playing critical roles in health and disease. Intact articular cartilage is an exquisite tissue that withstands incredible biologic and biomechanical demands in allowing movement and function, which is why hyaline cartilage must be maintained within a very narrow range of biochemical composition and morphologic architecture to meet demands while maintaining health and integrity. Unfortunately, insult, injury, and/or aging can initiate a cascade of events that result in erosion, degradation, and loss of articular cartilage such that joint pain and dysfunction ensue. Importantly, articular cartilage pathology affects the health of the entire joint and therefore should not be considered or addressed in isolation. Treating articular cartilage lesions is challenging because left alone, the tissue is incapable of regeneration or highly functional and durable repair. Nonoperative treatments can alleviate symptoms associated with cartilage pathology but are not curative or lasting. Current surgical treatments range from stimulation of intrinsic repair to whole-surface and whole-joint restoration. Unfortunately, there is a relative paucity of prospective, randomized controlled, or well-designed cohort-based clinical trials with respect to cartilage repair and restoration surgeries, such that there is a gap in knowledge that must be addressed to determine optimal treatment strategies for this ubiquitous problem in orthopedic health care. This review article discusses the basic science rationale and principles that influence pathology, symptoms, treatment algorithms, and outcomes associated with articular cartilage defects in the knee.

show abstract

Autologous Chondrocyte Implantation Versus Microfracture in the Knee: A Meta-analysis and Systematic Review

Cited by 49 publications

References 24 publications

High-Density Autologous Chondrocyte Implantation (HD-ACI) in patients with bilateral knee chondral defects

High-Density Autologous Chondrocyte Implantation (HD-ACI) in patients with bilateral knee chondral defects

Management of Large Focal Chondral and Osteochondral Defects in the Knee

Clinical Application of the Basic Science of Articular Cartilage Pathology and Treatment

Contact Info

Product

Resources

About