High-Density Autologous Chondrocyte Implantation (HD-ACI) in patients with bilateral knee chondral defects

Abstract

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Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

“…6,7 Currently, the methods used to treat cartilage defects include surgeries contain microfractures, autologous osteochondral transplantation, and autologous chondrocyte implantation. [8][9][10] These treatments can improve some of the symptoms, but some adverse reactions are reported. 11,12 In recent years, tissue engineering (TE) has made considerable progress in obtaining functional articular cartilage.…”

High density-autologous chondrocyte implantation for the treatment of bilateral ankle cartilage defects: Report of two cases

“…If patients' choice was to undergo one single surgery they only have to recover from one surgery while suffering the inconvenience of having both legs immobilized. 10 In that work we concluded that simultaneous treatment of chondral defects from both limbs with HD-ACI is a safe procedure with good results in terms of clinical outcome and quality of life. 10 Given the good results obtained in the knee we followed the same procedure with cartilage lesions in both ankles and 2 patients accepted to have just one surgery in which one ankle was operated after the other.…”

“…As described in a previous study conducted on patients with bilateral knee cartilage lesions, the main issue is to decide whether to operate both limbs in the same surgical act or in separate ones. 10 In this previous study, eight patients with bilateral knee chondral defects consecutively treated with HD-ACI, were included. We first explained the pros-and cons-of each option to patients and they decided whether they would like to undergo one or two surgeries.…”

“…We first explained the pros-and cons-of each option to patients and they decided whether they would like to undergo one or two surgeries. 10 If two surgeries was their choice, after recovering from the first surgery, patients would likely need to spend more time to return to previous activities, due to the burden of those two surgeries, yet on the other hand, these patients may have less mobility issues throughout their recovery time as just that one leg is immobilized after each surgery. If patients' choice was to undergo one single surgery they only have to recover from one surgery while suffering the inconvenience of having both legs immobilized.…”

“…9 We have recently published satisfactory results on the use of HD-ACI in patients with bilateral knee chondral defects. 10 In this work, we describe the treatment with HD-ACI in the same surgical act in 2 patients with bilateral ankle chondral lesions.…”