Autologous bone graft: Is it still the gold standard?

Schmidt, Andrew H.

doi:10.1016/j.injury.2021.01.043

Cited by 268 publications

(209 citation statements)

References 24 publications

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“… 1–3 Standard treatment strategies for bone defects employ autologous bone grafting, which has limited availability and may cause additional complications. 4 , 5 Allografts, as another potential clinical option, are rarely used because of the potential risks such as disease transmission and immune rejection. 6 , 7 …”

Section: Introductionmentioning

confidence: 99%

3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds Doped with Nano-Attapulgite for Bone Tissue Repair

Liu¹,

Qin²,

Wang³

et al. 2021

IJN

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Introduction Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications. The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair. Methods In this study, sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds doped with different contents of nano-attapulgite were fabricated via 3D printing. The surface microstructure, hydrophilicity and mechanical properties were fully evaluated. Furthermore, mouse bone marrow-derived mesenchymal stem cells (BMSCs) were cultured with the composite hydrogels in vitro, and proliferation and osteoblastic differentiation were assessed. A rabbit tibia plateau defect model was used to evaluate the osteogenic potential of the composite hydrogel in vivo. Results When increasing nano-ATP content, the Gel/SA/nano-ATP composite hydrogels showed better mechanical property and printability. Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days. The Gel/SA/nano-ATP composite hydrogel also showed good biocompatibility and promoted the osteogenesis of BMSCs. Finally, histological analysis demonstrates that the Gel/SA/nano-ATP composite hydrogels could effectively enhance bone regeneration in vivo. Conclusion These properties render the Gel/SA/nano-ATP composite hydrogel scaffolds an ideal bone tissue engineering material for the repair of bone defects.

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Section: Introductionmentioning

confidence: 99%

3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds Doped with Nano-Attapulgite for Bone Tissue Repair

Liu¹,

Qin²,

Wang³

et al. 2021

IJN

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show abstract

“…Biodegradable scaffolds, including calcium phosphate, aerogels [ 1 , 2 , 3 , 4 , 5 , 6 ], autologous [ 7 , 8 , 9 ], allogeneic [ 10 , 11 , 12 ], or xenogeneic grafts [ 13 , 14 , 15 , 16 , 17 ] demonstrate significant efficiency as bone substitute materials. Ideally, biocompatible materials’ resorption rate coincides with the formation rate of the new organotypic tissue.…”

Section: Introductionmentioning

confidence: 99%

Biopolymer Material from Human Spongiosa for Regenerative Medicine Application

et al. 2022

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Natural biopolymers demonstrate significant bone and connective tissue-engineering application efficiency. However, the quality of the biopolymer directly depends on microstructure and biochemical properties. This study aims to investigate the biocompatibility and microstructural properties of demineralized human spongiosa Lyoplast® (Samara, Russian Federation). The graft’s microstructural and biochemical properties were analyzed by scanning electron microscopy (SEM), micro-computed tomography, Raman spectroscopy, and proteomic analysis. Furthermore, the cell adhesion property of the graft was evaluated using cell cultures and fluorescence microscopy. Microstructural analysis revealed the hierarchical porous structure of the graft with complete removal of the cellular debris and bone marrow components. Moreover, the proteomic analysis confirmed the preservation of collagen and extracellular proteins, stimulating and inhibiting cell adhesion, proliferation, and differentiation. We revealed the adhesion of chondroblast cell cultures in vitro without any evidence of cytotoxicity. According to the study results, demineralized human spongiosa Lyoplast® can be effectively used as the bioactive scaffold for articular hyaline cartilage tissue engineering.

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“…A major clinical challenge in orthopedic and craniomaxillofacial (CMF) surgery is the development of critically sized bone defects typically caused by congenital malformations, trauma, infection, cancer, or surgical resection [1,2]. Multiple treatment approaches have been implemented to address such defects such as the use of allographs [3], however, the gold standard continues to be the use of autografts [4].…”

Section: Introductionmentioning

confidence: 99%

A New Bioink for Improved 3D Bioprinting of Bone-Like Constructs

Marsh

Apu

Bunn

et al. 2021

Preprint

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Bone tissue loss can occur due to disease, trauma or following surgery, in each case treatment involving the use of bone grafts or biomaterials is usually required. Recent development of three-dimensional (3D) bioprinting (3DBP) has enabled the printing of customized bone substitutes. Bioinks used for bone 3DBP employ various particulate phases such as ceramic and bioactive glass particles embedded in the bioink creating a composite. When composite bioinks are used for 3DBP based on extrusion, particles are heterogeneously distributed causing damage to cells due to stresses created during flow in the matrix of the composite. Therefore, the objective of this study was to develop cell-friendly osteopromotive bioink mitigating the risk of cell damage due to the flow of particles. Towards this end, we have linked organic and inorganic components, gelatin methacryloyl (GelMA) and Ag-doped bioactive glass (Ag-BaG), to produce a hybrid material, GelMA-Ag-BaG (GAB). The distribution of the elements present in the Ag-BaG in the resulting hybrid GAB structure was examined. Rheological properties of the resulting hydrogel and its printability, as well as the degree of swelling and degradation over time, were also evaluated. GAB was compared to GelMA alone and GelMA-Ag-BaG nanocomposites. Results showed the superiority of the hybrid GAB bioink in terms of homogenous distribution of the elements in the structure, rheological properties, printability, and degradation profiles. Accordingly, this new bioink represents a major advance for bone 3DBP.

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Autologous bone graft: Is it still the gold standard?

Cited by 268 publications

References 24 publications

3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds Doped with Nano-Attapulgite for Bone Tissue Repair

3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds Doped with Nano-Attapulgite for Bone Tissue Repair

Biopolymer Material from Human Spongiosa for Regenerative Medicine Application

A New Bioink for Improved 3D Bioprinting of Bone-Like Constructs

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