Autologous Blood Transfusion for Kidney Transplant Recipients

Sasaki, Hideo; Chikaraishi, Tatsuya; Furuhata, S.; Tsutsumi, Hisashi; Miyano, Satetsu; Nakazawa, Ryuto; Nakano, Toshiaki; Kudo, Hiroya; Kitajima, Kunio; Takahashi, Takeshi; Satoh, Y.; Kimura, Kenjiro

doi:10.1016/j.transproceed.2008.03.136

Cited by 4 publications

(3 citation statements)

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“…HLA molecules in the blood products are known to cause HLA allosensitization for blood transfusion recipients[ 11 - 13 ]. Various strategies have been attempted to avoid HLA allosensitization after blood transfusion, including leuko-reduced (leuko-depleted) blood products[ 11 , 14 ], HLA-selected blood products[ 15 ], and autologous blood transfusion[ 16 ]. However, the protective effects of these strategies are not well established[ 11 , 14 - 19 ].…”

Section: Discussionmentioning

confidence: 99%

Is peri-transplant blood transfusion associated with worse transplant outcomes? A retrospective study

Bukhari¹,

Alhomayani²,

Eid³

et al. 2023

World J Transplant

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BACKGROUND Blood transfusion is common during the peri-transplantation period. The incidence of immunological reactions to blood transfusion after kidney tran splantation and their consequences on graft outcomes have not been extensively studied. AIM To examine the risk of graft rejection and loss in patients who received blood transfusion in the immediate peri-transplantation period. METHODS We conducted a single-center retrospective cohort study of 105 kidney recipients, among them 54 patients received leukodepleted blood transfusion at our center between January 2017 and March 2020. RESULTS This study included 105 kidney recipients, of which 80% kidneys were from living-related donors, 14% from living-unrelated donors, and 6% from deceased donors. Living-related donors were mostly first-degree relatives (74.5%), while the rest were second-degree relatives. The patients were divided into transfusion ( n = 54) and non-transfusion ( n = 51) groups. The average hemoglobin level at which blood transfusion was commenced was 7.4 ± 0.9 mg/dL. There were no differences between the groups in terms of rejection rates, graft loss, or death. During the study period, there was no significant difference in creatinine level progression between the two groups. Delayed graft function was higher in the transfusion group; however, this finding was not statistically significant. A high number of transfused packed red blood cells was significantly associated with increased creatinine levels at the end of the study. CONCLUSION Leukodepleted blood transfusion was not associated with a higher risk of rejection, graft loss, or death in kidney transplant recipients.

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Section: Discussionmentioning

confidence: 99%

Is peri-transplant blood transfusion associated with worse transplant outcomes? A retrospective study

Bukhari¹,

Alhomayani²,

Eid³

et al. 2023

World J Transplant

View full text Add to dashboard Cite

show abstract

“…ABTs with HD were initially offered to patients ranging in age from children to the elderly, to provide blood for operations in several medical fields [21][22][23][24][25][26][27][28], the first and second predominant underlying conditions were kidney transplantation and orthopedic surgery. One case of ABT before surgery was for a patient with a high-titer anti-HLA antibody (Ab), to avoid development of additional anti-HLA during future kidney transplantation surgery [21].…”

Section: Discussionmentioning

confidence: 99%

“…Concerning potential adverse events related to ABT, coagulation in the dialyzer during HD was observed, possibly because of ESA [23], and two mild hypotension cases were also reported [28]. Vasovagal reflections including hypotension are the most common adverse event reported during collection of ABT [30,31].…”

Section: Upnmentioning

confidence: 99%