Autoimmunity: limited progress for the patient, despite decades of research

Delaleu, Nicolas; Peck, Ammon B.

doi:10.1111/j.1365-3083.2009.02318.x

Cited by 3 publications

(3 citation statements)

References 51 publications

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“…49 Indeed, at present, there are two clinically applicable protocols that result in long-term Figure 5. survival of (NZW x NZB) F 1 males started on 10 -3 M 2-Me at different ages.…”

Section: Discussionmentioning

confidence: 99%

Longevity of SLE-prone mice increased by dietary 2-mercaptoethanol via a mechanism imprinted within the first 28 days of life

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2010

Virulence

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“…49 Indeed, at present, there are two clinically applicable protocols that result in long-term Figure 5. survival of (NZW x NZB) F 1 males started on 10 -3 M 2-Me at different ages.…”

Section: Discussionmentioning

confidence: 99%

Longevity of SLE-prone mice increased by dietary 2-mercaptoethanol via a mechanism imprinted within the first 28 days of life

Click

2010

Virulence

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“…As the MVT’s ability to provoke predetermined immune responses is grounded in basic immunological principles, it can be expected that its application in humans will produce the same corrective immune response outcomes as observed in experimental animals. The MVT promises to provide the long awaited answer for prevention and cure of autoimmune disorders [92].…”

Section: Resultsmentioning

confidence: 99%

Modified Vaccination Technique for Prophylactic and Therapeutic Applications to Combat Endogenous Antigen–Induced Disorders

et al. 2010

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Public health can be protected most effectively through vaccination programmes. However, while presently available vaccination techniques protects the individual by provoking immune responses against exogenous antigens (ags), such as those associated with certain bacteria and viruses, they cannot protect against or treat mishaps caused by endogenous ag. Recently, Barabas and colleagues have developed a new vaccination method, called modified vaccination technique (MVT), which allows the presentation of disease causing agents in such a way as to initiate and maintain desired immune response outcomes even in the context of mishaps associated with endogenous ag. For example, in an experimental autoimmune kidney disease, the MVT downregulated/terminated pathogenic immune responses that were causing morphological and functional changes of the kidney. The MVT promises, with appropriate case‐specific modifications, both preventative and curative applications for ailments, such as endogenous ag initiated mishaps (i.e. autoimmune diseases and cancer) and diseases caused by chronic infection, that are presently only treatable with drugs. To achieve specific immune responses, purified components of the vaccine (ag and antibodies) must be produced and assembled into immune complexes having the potential of inducing predetermined corrective immune response outcomes.

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“…An estimated 50 million Americans have been diagnosed with autoimmune diseases (American Autoimmune Related Diseases Association, n.d.‐a), which can include commonly known chronic illnesses, such as Crohn's disease, ulcerative colitis, lupus, celiac disease, and rheumatoid arthritis (American Autoimmune Related Diseases Association, n.d.‐b). The fields of medicine and public health have historically struggled to strictly define and categorize autoimmune disorders (ADs) because of the broad range of health issues that may be classified as such (Delaleu & Peck, ), but generally, ADs are “specific, adapted immune reactions against specific self antigens” (Serefhanoglu, Tapan, Ertenli, Kalyoncu, & Uner, , p. 826), meaning that an individual's immune system may sometimes attack perfectly healthy body cells and tissue by mistake. Very often, the onset of an AD may be triggered by considerable stress (O'Leary, ), such as dealing with the loss of a partner, remaining in the closet, coming out as gay and dealing with the aftermath, or experiencing a long period of unemployment.…”

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confidence: 99%