Autoimmunity, Infectious Immunity, and Atherosclerosis

Matsuura, Eiji; Kobayashi, Kazuo; Matsunami, Yukana; Shen, Lianhua; Quan, Nanhu; Makarova, Marina; Suchkov, Sergey; Ayada, Kiyoshi; Oguma, Keiji; Lopez, Luis R.

doi:10.1007/s10875-009-9333-5

Cited by 34 publications

(23 citation statements)

References 49 publications

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“…After challenge with HSP, plaque-derived T cells expressed Th1 functions, became cytotoxic, and induced tissue factor production in macrophages [41] . The results of the recent study by Matsuura et al [42] also indicated that the systemic Th1-immune response against Hp-HSP60 induced by Helicobacter pylori infection in the gastric mucosa might promote atherosclerosis because elevated production of Th1-cytokines, such as IFN-␥ and IL-12, was observed as well as expression of T-bet mRNA (Th1-polarization marker) [42] . Overall, these results provide convincing elements to incriminate Th1-related responses in the promotion of atherosclerotic plaque development and progression ( fig.…”

Section: Th1 Immunity In Atherosclerosismentioning

confidence: 99%

Emerging Role of IL-17 in Atherosclerosis

Chen

Crother

Arditi³

2010

J Innate Immun

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The IL-23-IL-17 axis is emerging as a critical regulatory system that bridges the innate and adaptive arms of the immune system. Th17 cells have been linked to the pathogenesis of several chronic inflammatory and autoimmune diseases. However, the role of Th17 cells and IL-17 in various stages of atherogenesis remains poorly understood and is only beginning to be elucidated. While IL-17 is a predominantly proinflammatory cytokine, it has a pleiotropic function and it has been implicated both as an instigator in the pathogenesis of several inflammatory disorders as well as being protective in certain inflammatory disease models. Therefore, it is not surprising that the current literature is conflicting on the role of IL-17 during atherosclerotic lesion development. Various approaches have been used by several groups to discern the involvement of IL-17 in atherosclerosis. While one study found that IL-17 is protective against atherosclerosis, several other recent studies have suggested that IL-17 plays a proatherogenic role. Thus, the function of IL-17 remains controversial and awaits more direct studies to address the issue. In this review, we will highlight all the latest studies involving IL-17 and atherosclerosis, including both clinical and experimental research.

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Section: Th1 Immunity In Atherosclerosismentioning

confidence: 99%

Emerging Role of IL-17 in Atherosclerosis

Chen

Crother

Arditi³

2010

J Innate Immun

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“…There is a growing body of evidence suggesting that inflammation associated with persistent infection may contribute to the development of cardiovascular disease and other chronic diseases of aging [9-11]. In certain cases, particular pathogens have been linked to chronic disease.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of 13 common pathogens in a rapidly growing U.S. minority population: Mexican Americans from San Antonio, TX

et al. 2011

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BackgroundInfection risks vary among individuals and between populations. Here we present information on the seroprevalence of 13 common infectious agents in a San Antonio-based sample of Mexican Americans. Mexican Americans represent the largest and most rapidly growing minority population in the U.S., and they are also considered a health disparities population.MethodsWe analyzed 1227 individuals for antibody titer to Chlamydophila pneumoniae, Helicobacter pylori, Toxoplasma gondii, cytomegalovirus, Epstein-Barr virus, herpes simplex virus-1, herpes simplex virus-2 (HSV-2), human herpesvirus-6 (HHV-6), varicella zoster virus (VZV), adenovirus-36, hepatitis A virus, and influenza A and B. Seroprevalence was examined as a function of sex, age, household income, and education.ResultsSeroprevalence estimates ranged from 9% for T. gondii to 92% for VZV, and were similar in both sexes except for HSV-2, which was more prevalent in women. Many pathogens exhibited a significant seroprevalence change over the examined age range (15-94 years), with 7 pathogens increasing and HHV-6 decreasing with age. Socioeconomic status significantly correlated with serostatus for some pathogens.ConclusionsOur findings demonstrate substantial seroprevalence rates of these common infections in this sample of Mexican Americans from San Antonio, Texas that suffers from high rates of chronic diseases including obesity and type-2 diabetes.

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“…CRP is the principal down-stream mediator of inflammatory acute phase response, which is primarily derived via interleukin 6-dependent hepatic biosynthesis (Pradhan et al, 2001). CRP interacts with oxidized LDL to form proatherogenic oxidized LDL/CRP complexes, perpetuating vascular inflammation, triggering an autoimmune response, and accelerating atherogenesis (Matsuura et al, 2009;Sitia et al, 2010). Activation of the renin-angiotensin system (RAS) by stress also plays a role in the pathogenesis of endothelial dysfunction, hypertension and atherosclerosis.…”

Section: Stress Dyslipidemia and Atherosclerosis: Putative Mechanismsmentioning

confidence: 99%