2017
DOI: 10.12945/j.aorta.2017.17.693
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Autoimmunity in the Abdominal Aortic Aneurysm and its Association with Smoking

Abstract: Smoking increases the risk of abdominal aortic aneurysm (AAA) in both humans and mice, although the underlying mechanisms are not completely understood. An adventitial aortic antigen, AAAP-40, has been partially sequenced. It has motifs with similarities to all three fibrinogen chains and appears to be connected in evolution to a large family of proteins called fibrinogen-related proteins. Fibrinogen may undergo non-enzymatic nitration, which may result from exposure to nitric oxide in cigarette smoke. Nitrati… Show more

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Cited by 7 publications
(4 citation statements)
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“…AAA risk was increased in patients with autoimmune diseases such as lupus and psoriasis [57][58][59][60][61], and anti-rheumatic therapies were associated with reduced rates of AAA enlargement [62]. While autoantigens and other autoimmunity components may contribute to AAA disease [63,64], the current findings linking IFNAR1 to experimental AAA pathogenesis provide further insights into the positive association between autoimmune diseases and aortic aneurysms.…”
Section: Discussionmentioning
confidence: 79%
“…AAA risk was increased in patients with autoimmune diseases such as lupus and psoriasis [57][58][59][60][61], and anti-rheumatic therapies were associated with reduced rates of AAA enlargement [62]. While autoantigens and other autoimmunity components may contribute to AAA disease [63,64], the current findings linking IFNAR1 to experimental AAA pathogenesis provide further insights into the positive association between autoimmune diseases and aortic aneurysms.…”
Section: Discussionmentioning
confidence: 79%
“…This could occur as an initial response to environmental triggers that, in combination with risk factors, e.g. smoke (Tilson, 2017), in genetically susceptible individuals may lead to immunopathogenic T-cell responses that contribute to the development and the progression of the disease.…”
Section: Discussionmentioning
confidence: 99%
“…g . smoke (Tilson, 2017), in genetically susceptible individuals may lead to immunopathogenic T-cell responses that contribute to the development and the progression of the disease.…”
Section: Discussionmentioning
confidence: 99%
“…The SNP rs1024611 was in Hardy-Weinberg equilibrium in patients, which was assessed using the c 2 test. Known alleles that were significantly associated with disease outcome were also examined using logistic regression, and significant differences were tested by nonparametric statistics using the STATA v. 14…”
Section: Discussionmentioning
confidence: 99%