Investigation of an Immunogenetic Profile in Patients with Abdominal Aortic Aneurysms and Possible Applications in Screening and Surveillance

Anaya‐Ayala, Javier E.; Escamilla-Tilch, Mónica; Granados, Jesús Benítez; Hernández-Doño, Susana; Hernandez-Sotelo, Kemberly; Lozano-Corona, Rodrigo; Gómez, Daniela Ruiz; Garcia-Toca, Manuel; Hinojosa, Carlos A.

doi:10.1016/j.avsg.2019.05.004

Cited by 5 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the up-regulation of HLA-DR is related to the occurrence and development of AAA, but a prospective observational study also pointed out an interesting phenomenon: a decrease in the percentage of HLA-DR monocytes in patients who died after AAA surgery may indicate an increased risk of death, which may suggest that the expression of HLA-DR in different pathological stages and immune cells can lead to complex pathological and physiological outcomes [ 25 ]. In a cohort of AAA patients from Mexico, other researchers found that the frequencies of HLA-DRB1*01 and HLA-DRB1*16 in AAA patients were significantly elevated compared with those in healthy people [ 26 ]. In addition, in an in vitro experiment, Dragana Vucevic and her colleagues found that there was a higher percentage of HLA-DR+ immune cells in AAA tissue than in plasma [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Adenosine 5′-Monophosphate-to-Threonine Ratio Promotes Abdominal Aortic Aneurysms via Up-Regulation of HLA-DR on Natural Killer Cells: A Bidirectional Mendelian Randomized Analysis

Teng,

Tang,

et al. 2024

Biomedicines

View full text Add to dashboard Cite

Objective: Immune–metabolic interactions may have causal and therapeutic impacts on abdominal aortic aneurysms (AAAs). However, due to the lack of research on the relationship between immune–metabolic interactions and AAAs, further exploration of the mechanism faces challenges. Methods: A two-sample, two-step mediation analysis with Mendelian randomization (MR) based on genome-wide association studies (GWASs) was performed to determine the causal associations among blood immune cell signatures, metabolites, and AAAs. The stability, heterogeneity, and pleiotropy of the results were verified using a multivariate sensitivity analysis. Results: After multiple two-sample MRs using the AAA data from two large-scale GWAS databases, we determined that the human leukocyte antigen-DR (HLA-DR) levels on HLA-DR + natural killer (NK) cells (HLA-DR/NK) were associated with the causal effect of an AAA, with consistent results in the two databases (FinnGen: odds ratio (OR) = 1.054, 95% confidence interval (CI): 1.003–1.067, p-value = 0.036; UK Biobank: OR = 1.149, 95% CI: 1.046–1.261, p-value = 0.004). The metabolites associated with the risk of developing an AAA were enriched to find a specific metabolic model. We also found that the ratio of adenosine 5′-monophosphate (AMP) to threonine could act as a potential mediator between the HLA/NK and an AAA, with a direct effect (beta effect = 0.0496) and an indirect effect (beta effect = 0.0029). The mediation proportion was 5.56%. Conclusions: Our study found that an up-regulation of HLA-DR on HLA-DR/NK cells can increase the risk of an AAA via improvements in the AMP-to-threonine ratio, thus providing a potential new biomarker for the prediction and treatment of AAAs.

show abstract

Section: Discussionmentioning

confidence: 99%

Adenosine 5′-Monophosphate-to-Threonine Ratio Promotes Abdominal Aortic Aneurysms via Up-Regulation of HLA-DR on Natural Killer Cells: A Bidirectional Mendelian Randomized Analysis

Teng,

Tang,

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

“…This confirmed that in the 4 metropolitan areas included in this trial, the frequency of this disease does not seem significantly different from that in at-risk populations from other international registries. This has led us to further investigate possible genetic factors in Mexican mestizo individuals at risk of developing AAA 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Efforts for detection of aortic aneurysms and human resources training for the optimization of their treatment

Hinojosa-Becerril,

Anaya-Ayala,

Bobadilla-Rosado

et al. 2024

CIRUE

View full text Add to dashboard Cite

Objective: To review admissions, interventions and in-hospital mortality associated to Abdominal Aortic Aneurysms (AAA), and to analyze the impact of the introduction of a training program and imaging screening at our institution. Methods: Retrospective study where hospitalizations, procedures and mortality secondary to AAA were recorded. The national databases (ND) from the Secretariat of Health were utilized from 2010 to 2020. In-hospital lethality was calculated and compared with the experience at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ). The statistical analysis was completed with the STATA version 17. Results: According to the ND, 899 (91%) hospital admissions secondary to AAA occurred, while in the INCMNSZ 85 (9%). Most of them belonged to the male gender (68%); 811 (82%) patients underwent open surgical repair, and 173 (18%) to an endovascular exclusion (EVAR), the latter approach was significantly more frequently performed at our institution (p = 0.007). The 30-day hospital mortality was 22.5%; in the ND was 23.9 vs. a 16.4% in the INCMNSZ without significant difference (p = 0.1). Conclusions: AAA remain unrecognized in our country. The introduction of University programs and imaging screening might impact in the early detection, and to reduce the morbidity and mortality associated to emergency procedures.

show abstract

“…Desde entonces y como parte de una iniciativa de la presente administración de la Sociedad Mexicana de Angiología, Cirugía Vascular y Endovascular A.C. (SMACVE), los esfuerzos han continuado, y en el primer estudio multicéntrico llevado a cabo en nueve instituciones encontramos una prevalencia de AAA del 3.08% 8 , confirmando que en las cuatro áreas metropolitanas incluidas en este esfuerzo, la frecuencia de esta patología no parece ser tan diferente en proporción con la población en riesgo de otros registros internacionales. Esto nos ha llevado a la investigación más profunda de posibles factores genéticos en los mexicanos mestizos en riesgo a desarrollar AAA 9,10 .…”

Section: Introductionunclassified

Esfuerzos en la detección de aneurismas aórticos y la formación de recursos humanos para la optimización de su tratamiento

Hinojosa-Becerril,

Anaya-Ayala,

Bobadilla-Rosado

et al. 2023

CIRU

View full text Add to dashboard Cite

Objetivo: Revisar los ingresos, procedimientos y defunciones intrahospitalarias asociadas a aneurismas aórticos abdominales (AAA) y analizar el impacto de la introducción de programas de formación de recursos humanos y tamizaje ultrasonográfico. Métodos: Estudio retrospectivo, se analizaron las bases de datos nacionales obtenidas del portal datos abiertos de la Dirección General de Información en Salud (DGIS) del año 2010 al 2020. Se calculó la letalidad intrahospitalaria anual y comparamos la experiencia del Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ). El análisis estadístico se realizó en el programa STATA versión 17. Resultados: De acuerdo con la base nacional (BN), se registraron 899 (91%) ingresos, mientras que en el INCMNSZ 85 (9%). La mayoría pertenecía al sexo masculino (68%), un total de 811 (82%) pacientes fueron sometidos a cirugía abierta, mientras que 173 (18%) a terapia endovascular (EVAR), siendo este abordaje más frecuente en nuestra institución (p = 0.007). La mortalidad intrahospitalaria fue del 22.5%, en la BN fue del 23.9%, mientras que en el INCMNSZ fue del 16.4%, sin que encontráramos diferencia significativa (p = 0.1). Conclusiones: Los AAA continúan siendo poco reconocidos en nuestro país. La introducción de programas universitarios de especialidad y el tamizaje podría impactar en la reducción de la morbimortalidad.

show abstract

Investigation of an Immunogenetic Profile in Patients with Abdominal Aortic Aneurysms and Possible Applications in Screening and Surveillance

Cited by 5 publications

References 32 publications

Adenosine 5′-Monophosphate-to-Threonine Ratio Promotes Abdominal Aortic Aneurysms via Up-Regulation of HLA-DR on Natural Killer Cells: A Bidirectional Mendelian Randomized Analysis

Adenosine 5′-Monophosphate-to-Threonine Ratio Promotes Abdominal Aortic Aneurysms via Up-Regulation of HLA-DR on Natural Killer Cells: A Bidirectional Mendelian Randomized Analysis

Efforts for detection of aortic aneurysms and human resources training for the optimization of their treatment

Esfuerzos en la detección de aneurismas aórticos y la formación de recursos humanos para la optimización de su tratamiento

Contact Info

Product

Resources

About