Autoimmunity and antigenic targets in ovarian pathology

Forges, Thierry; Monnier‐Barbarino, Patricia; Fauré, G; Béné, Marie C.

doi:10.1093/humupd/dmh014

Cited by 151 publications

(119 citation statements)

References 132 publications

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“…[43][44][45][46] It seems likely that as with SC antibodies, multiple and shared antigens among endocrine organs raises susceptibility of involvement of multiple organs, including the ovary.…”

Section: Autoimmune Oophoritis As a Cause For Primary Ovarian Insuffimentioning

confidence: 99%

Ovarian autoimmune disease: clinical concepts and animal models

et al. 2014

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The ovary is not an immunologically privileged organ, but a breakdown in tolerogenic mechanisms for ovary-specific antigens has disastrous consequences on fertility in women, and this is replicated in murine models of autoimmune disease. Isolated ovarian autoimmune disease is rare in women, likely due to the severity of the disease and the inability to transmit genetic information conferring the ovarian disease across generations. Nonetheless, autoimmune oophoritis is often observed in association with other autoimmune diseases, particularly autoimmune adrenal disease, and takes a toll on both society and individual health. Studies in mice have revealed at least two mechanisms that protect the ovary from autoimmune attack. These mechanisms include control of autoreactive T cells by thymus-derived regulatory T cells, as well as a role for the autoimmune regulator (AIRE), a transcriptional regulator that induces expression of tissue-restricted antigens in medullary thymic epithelial cells during development of T cells. Although the latter mechanism is incompletely defined, it is well established that failure of either results in autoimmune-mediated targeting and depletion of ovarian follicles. In this review, we will address the clinical features and consequences of autoimmune-mediated ovarian infertility in women, as well as the possible mechanisms of disease as revealed by animal models.

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Section: Autoimmune Oophoritis As a Cause For Primary Ovarian Insuffimentioning

confidence: 99%

Ovarian autoimmune disease: clinical concepts and animal models

et al. 2014

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“…These autoantibodies have been detected in several human cancers, and significant advances have been made in the identification of their target antigens, particularly in lung cancer (28,30), colorectal cancer (36), breast cancer (29), prostate cancer (27,37), leukemia (26), non-Hodgkin lymphoma (24), hepatocellular carcinoma (25,32,34), ovarian cancer (31), pancreatic cancer (33,38), and paraneoplastic neurological syndromes (35). Although the mechanisms leading to autoantibody production in cancer patients are not clearly understood, emerging evidence indicates that most TAAs are cellular proteins whose aberrant regulation or function could be linked to malignancy (3).…”

Section: Cancer-associated Autoantibodies As Reporters Of Tumorigenesismentioning

confidence: 99%

Tumor-associated Antigen Arrays for the Serological Diagnosis of Cancer

Casiano

Mediavilla-Varela

Tan

2006

Molecular & Cellular Proteomics

121

106

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The recognition that human tumors stimulate the production of autoantibodies against autologous cellular proteins called tumor-associated antigens (TAAs) has opened the door to the possibility that autoantibodies could be exploited as serological tools for the early diagnosis and management of cancer. Cancer-associated autoantibodies are often driven by intracellular proteins that are mutated, modified, or aberrantly expressed in tumor cells and hence are regarded as immunological reporters that could help uncover molecular events underlying tumorigenesis. Emerging evidence suggests that each type of cancer might trigger unique autoantibody signatures that reflect the nature of the malignant process in the affected organ. The advent of novel genomic, proteomic, and high throughput approaches has accelerated interest in the serum autoantibody repertoire in human cancers for the discovery of candidate TAAs. The use of individual anti-TAA autoantibodies as diagnostic or prognostic tools has been tempered by their low frequency and heterogeneity in most human cancers. However, TAA arrays comprising several antigens significantly increase this frequency and hold great promise for the early detection of cancer, monitoring cancer progression, guiding individualized therapeutic interventions, and identification of novel therapeutic targets. Our recent studies suggest that the implementation of TAA arrays in screening programs for the diagnosis of prostate cancer and other cancers should be preceded by the optimization of their sensitivity and specificity through the careful selection of the most favorable combinations of TAAs.

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“…Several lines of evidence indicate that autoimmunity is responsible for several ovarian disorders including POF, endometriosis, unexplained infertility, and PCOS [8,15]. Detection of AOA in these patients is suggestive of an autoimmune process in pathogenesis of the disease.…”

Section: Discussionmentioning

confidence: 97%

Serum Levels of Anti-histone and Anti-double-Strand DNA Antibodies Before and After Laparoscopic Ovarian Drilling in Women with Polycystic Ovarian Syndrome

Samsami

Razmjoei

Parsanezhad

2013

J Obstet Gynecol India

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Objectives To determine the serum levels of anti-dsDNA, anti-histone, and anti-nucleosome antibodies after laparoscopic ovarian electrocauterization in patients with polycystic ovarian syndrome (PCOS). Methods Our study was performed on 35 patients with PCOS resistant to medical therapy, 35 patients with unexplained infertility, and 35 healthy fertile individuals. Patients with PCOS underwent laparoscopic electrocauterization while those with unexplained infertility underwent diagnostic laparoscopy. Serum levels of anti-dsDNA, anti-histone, and anti-nucleosome antibodies were measured at baseline and 1 month after operation and were compared between groups.

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Autoimmunity and antigenic targets in ovarian pathology

Cited by 151 publications

References 132 publications

Ovarian autoimmune disease: clinical concepts and animal models

Ovarian autoimmune disease: clinical concepts and animal models

Tumor-associated Antigen Arrays for the Serological Diagnosis of Cancer

Serum Levels of Anti-histone and Anti-double-Strand DNA Antibodies Before and After Laparoscopic Ovarian Drilling in Women with Polycystic Ovarian Syndrome

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