Autoimmune Thrombocytopenia in Renal Carcinoma

Enright, Helen; Angus, D. G.

doi:10.1111/j.1464-410x.1989.tb05170.x

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“…This often leads to improvement in thrombocytopenia. Sustained complete remission has been reported following surgical resection alone, while sustained remission has been described following splenectomy together in combination with surgical resection of malignancy [15,16]. In certain cases, danazol, when tried prior to tumor resection in the patient with RCC, led to improvement in platelet counts [17].…”

Section: Discussionmentioning

confidence: 99%

Secondary Immune Thrombocytopenic Purpura in Renal Cell Cancer: A Paraneoplastic Syndrome

Noor¹,

Rehan²,

Desai³

et al. 2019

Cureus

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Secondary immune thrombocytopenic purpura (ITP) as a paraneoplastic syndrome has been reported in literature. It is commonly associated with chronic lymphocytic leukemia (CLL) and hodgkins lymphoma. Its association with solid malignancies, especially renal cell cancer is rare, with only a few documented case reports. Treatment usually consisted of targeting the underlying malignancy or utilization of steroid and intravenous immunoglobulin (IVIG) to improve thrombocytopenia. Here, we describe a case of a 75-year-old man with renal cell cancer (RCC), who presented with secondary thrombocytopenia treated with steroid and IVIG. It is important to keep RCC in differential diagnosis for causes for secondary ITP as this impacts treatment.

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Section: Discussionmentioning

confidence: 99%