Autoimmune responses to human tumour antigens.

Hodkinson, Madeline; Taylor, Geoffrey

doi:10.1038/bjc.1969.63

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…The possible existence of a defense reaction of the cancer patient against his own malignant tumor is of high clinical interest and has incited numerous investigations reporting both positive and negative results (Graham and Graham, 1955;Itoh and Southam, 1964;Hodkinson and Taylor, 1969;Hellstrom et al, 1970).…”

mentioning

confidence: 99%

Further investigations of circulating antibodies in colon cancer patients: On the autoantigenicity of the carcinoembryonic antigen

Collatz

Kleist

Burtin

1971

Intl Journal of Cancer

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confidence: 99%

Further investigations of circulating antibodies in colon cancer patients: On the autoantigenicity of the carcinoembryonic antigen

Collatz

Kleist

Burtin

1971

Intl Journal of Cancer

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“…Furthermore, TPS antigens, unlike CEA, are not cell‐surface cancer‐associated antigens but rather cancer‐specific antigens of mitochondrial origin. Hodkinson and Taylor (91) have confirmed the presence of tumour‐specific antigens in mitochondrial (but not microsomal) preparations of carcinoma of the rectum, and also have shown that an autoimmune response to these antigens may occur.…”

Section: Autosensitization and Cancermentioning

confidence: 96%

Autosensitization Cell Membrane Diseases: A Unifying Concept of Autoimmune Diseases, Collagen Diseases, Neuromyopathies and Cancer

Makari

1972

J American Geriatrics Society

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It is proposed that the term "autosensitization cell membrane (ACM) diseases" be applied to a conglomerate of disorders in which there apparently is a state of autosensitization to common glycolipid plasma membrane (GPM) antigens. Except for cancer, all the other ACM diseases may be the result of this autosensitization to GPM antigens. These disorders are subdivided on the basis of the cell source of GPM, whether from erythrocytes as in autoimmune haemolytic anaemia, from endothelial cells as in collagen diseases, from epithelial cells as in organ-specific immune diseases, or from nerve cells as in neuromyopathies. In cancer, two types of autosensitization occur. The first is autosensitization t o GPM originating from damaged normal cells adjoining cancer cells. The second is autosensitization to cancer-specific tumour polysaccharide substance (TPS) antigens originating in the cancer cells themselves. Evidence for this hypothesis is presented. THE COMMON ANTIGENA glycolipid substance present as a component of certain cell membranes is apparently the common antigen that gives rise to auto-

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Evidence for Membrane-Bound Antibodies Directed against Antigens Expressed on Tumors

Kleist

King

Huet

1980

In Situ Expression of Tumor Immunity

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Autoimmune responses to human tumour antigens.

Cited by 4 publications

References 9 publications

Further investigations of circulating antibodies in colon cancer patients: On the autoantigenicity of the carcinoembryonic antigen

Further investigations of circulating antibodies in colon cancer patients: On the autoantigenicity of the carcinoembryonic antigen

Autosensitization Cell Membrane Diseases: A Unifying Concept of Autoimmune Diseases, Collagen Diseases, Neuromyopathies and Cancer

Evidence for Membrane-Bound Antibodies Directed against Antigens Expressed on Tumors

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