Evidence for Membrane-Bound Antibodies Directed against Antigens Expressed on Tumors

Kleist, S. von; King, M.; Huet, Christian

doi:10.1007/978-1-4684-3677-8_8

Cited by 2 publications

(1 citation statement)

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“…This may be due to binding of the antibodies to the corresponding antigen to form soluble circulating complexes or the antibodies may bind specifically to the tumour cell membranes. There is experimental evidence for both possibilities [100]. The presence of these antibodies in the sera of supposedly healthy blood donors suggests that they are not directly linked with an attack on the tumour.…”

Section: H3 Antibodiesmentioning

confidence: 96%

Immune surveillance and natural resistance: an evaluation

Otter

1986

Cancer Immunol Immunother

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Concepts in tumour immunology are changing fundamentally. Around 1970 tumour immunology contained the following related concepts: Thousands of tumour cells arise de novo each day. Tumour cells are antigenic in their host. All these antigenic tumour cells are killed by a strong immune surveillance system. A more likely set of concepts looks as follows: Tumour cells do not arise frequently. Tumour cells may be antigenic or not. There is no need to postulate a very strong immune surveillance or natural resistance system. In this paper I am reviewing our present knowledge of immune surveillance and natural resistance. Only scanty information appears to be available. This information suggests that virally induced tumours are usually killed by cytotoxic T lymphocytes, and natural killer cells, whereas immune surveillance and natural resistance against other tumours may be quite weak.

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Section: H3 Antibodiesmentioning

confidence: 96%