Autoimmune progesterone dermatitis: Case report with history of urticaria, petechiae and palpable pinpoint purpura triggered by medical abortion

Mbonile, Lumuli

doi:10.7196/samj.2016.v106i4.9896

Cited by 11 publications

(18 citation statements)

References 26 publications

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“…The most common symptoms of AIPD include urticaria (n = 50), pruritus (n = 27), angioedema (n = 21), and erythema multiforme (n = 19). Symptoms of AIPD begin 3 to 10 days prior to and resolve 1 to 2 days after menses (Anderson, 1984, Asai et al, 2009, Bandino et al, 2011, Baptist and Baldwin, 2004, Berger, 1969, Bernstein et al, 2011, Bolaji and O'Dwyer, 1992, Camoes et al, 2017, Chawla et al, 2009, Choi et al, 2009, Cocuroccia et al, 2006, Cristaudo et al, 2007, Dedecker et al, 2005, Detrixhe et al, 2017, Domeyer-Klenske et al, 2015, Drayer et al, 2018, Farah and Shbaklu, 1971, Foer et al, 2016, Fournier, 2015, Frieder and Younus, 2016, Garcia-Ortega and Scorza, 2011, George and Badawy, 2012, Georgouras, 1981, Grunnet et al, 2017, Hacinecipoglu et al, 2016, Halevy et al, 2002, Hart, 1977, Herzberg et al, 1995, Hill and Carr, 2013, Honda et al, 2014, Izu et al, 2001, Jenkins et al, 2008, Jones and Gordon, 1969, Kakarla and Zurawin, 2006, Katayama and Nishioka, 1985, Kaygusuz et al, 2014, Lahmam Bennani et al, 2012, Le and Wood, 2011, Lee et al, 1992, Lee et al, 2011, Mbonile, 2016, Medeiros et al, 2010, Moghadam et al, 1998, Mokhtari et al, 2017, Moody and Schatten, 1997, Nasabzadeh et al, 2010, Nemeth et al, 2009, Oskay et al, 2002, Ozmen and Akturk, 2016, Poffet et al, 2011, Prieto-Garcia et al, 2011, Rasi and Khatami, 2004, Rodenas et al, 1998, Salman and Ergun, 2017, Shahar et al, 1997, Snyder and Krishnaswamy, 2003, Stephens et al, 1989, Stone and Downham, 1981, Teelucksingh and Edwards, 1990, Toms-Whittle et al, 2011, Tromovitch and Heggli, 1967, Vasconcelos et al, 2000, Walling and Scupham, 2008, …”

Section: Resultsmentioning

confidence: 99%

Catamenial dermatoses associated with autoimmune, inflammatory, and systemic diseases: A systematic review,,

Zachary

Fackler

Juhász

et al. 2019

International Journal of Women's Dermatology

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BackgroundSex hormones are important in female sexual physiology, growth, and homeostasis. Through skin receptors, sex hormones contribute to the dermatologic pathology known as catamenial dermatoses.ObjectiveThis study aims to summarize the literature on catamenial dermatoses and menses-induced exacerbations of chronic dermatoses.MethodsThis systematic review used the PRISMA method. PubMed was searched using the terms “menses” and “skin” in July 2018, and an assessment was conducted of the relevant literature on skin diseases related to non-pathologic menstruation, such as polycystic ovarian syndrome. Pathology associated with androgenetic acne was excluded from the study.ResultsA total of 102 studies with 1269 female patients were included. The most commonly reported primary catamenial dermatoses were autoimmune progesterone dermatitis and autoimmune estrogen dermatitis. The most commonly reported chronic skin disorders exacerbated by menses were psoriasis, Behcet’s disease, and eczematous dermatoses.ConclusionPhysicians should be aware of the nature of catamenial dermatoses and their presentation with normal sexual physiology. Patients with chronic dermatoses should be appropriately counseled on menstruation-related exacerbations. Further research needs to be conducted to determine the interplay between immune regulation and sex hormones in catamenial dermatoses and to elucidate effective therapies.

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Section: Resultsmentioning

confidence: 99%

Catamenial dermatoses associated with autoimmune, inflammatory, and systemic diseases: A systematic review,,

Zachary

Fackler

Juhász

et al. 2019

International Journal of Women's Dermatology

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“…Initially, most cases were associated with exogenous progesterone intake (3); on an extensive review of published data, only 44.95% of patients recalled exogenous progesterone exposure, however, there was a lack of recorded history for 35.96% of patients (4). Onset of the disease was also noted in relation to pregnancy, intrapartum, postpartum or after medical abortion (5).…”

Section: Discussionmentioning

confidence: 99%

Progesterone hypersensitivity: Case report with favorable evolution

et al. 2018

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Progesterone hypersensitivity or autoimmune progesterone dermatitis is characterized by heterogeneous skin eruptions that cyclically aggravate during the second half of the menstrual cycle, corresponding to a rise in the progesterone level. Clinical presentation is highly variable and includes all urticaria manifestations with or without angioedema, vesiculobullous, eczematous, purpuric or target-like lesions on the skin and mucous membrane. Both endogenous progesterone as well as exogenous progestogens may represent an initial trigger. We report a case of progesterone hypersensitivity in a 27-year old woman with favorable evolution only on topical therapy, the positive clinical outcome being maintained during a subsequent pregnancy and postpartum period.

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“…Patients usually present with localized cutaneous or systemic symptoms, although a given patient's reaction may evolve with time and vary from month to month. Patients can present with multiple cutaneous reactions, 15 including maculopapular rash, papules and plaques, 16,17 eczematous dermatitis, 18,19 urticaria with or without angioedema, 20e25 vesiculobullous and/or vesiculopusutular lesions, 7,16 petechiae and purpura, 5,26 stomatitis, 27,28 vulvovaginal pruritus, 29 erythema multiforme, 30,31 fixed drug eruption, 32,33 or Stevens-Johnson syndrome. 34,35 In each of these cases, PH was confirmed through positive progesterone skin testing (immediate epicutaneous and intracutaneous testing, delayed intracutaneous testing response, or patch testing), a progesterone challenge that provoked symptoms or clear improvement with treatment, which are discussed below.…”

Section: Catamenial Hypersensitivitymentioning

confidence: 99%

Cyclical hypersensitivity, anaphylaxis, and related hormonal reaction

Lavery

Bernstein

2019

Annals of Allergy, Asthma & Immunology

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Although endogenous or exogenous exposure to progesterone or estrogen that induce a spectrum of hypersensitivity reactions and/or other skin eruptions are believed to be uncommon, their prevalence is currently unknown. Clinical manifestations are heterogeneous but typically involve cyclical manifestation of a spectrum of dermatitis conditions and/or systemic symptoms. Diagnosis is made primarily by history in conjunction with in vitro assays to measure specific IgE and provocation challenge testing when appropriate; judicious use of skin testing is recommended because of their irritant-causing effects. Pathomechanisms are incompletely understood but likely involve IgE-mediated immediate-type hypersensitivity. Treatment is aimed at symptomatic control with nonsedating histamine 1 antihistamines, short-term use of systemic glucocorticoids, progesterone desensitization, and/or suppression of ovulation by a pharmacologic or, as a last resort, surgical approach. Instructions Credit can now be obtained, free for a limited time, by reading the review article and completing all activity components. Please note the instructions listed below: Review the target audience, learning objectives and all disclosures. Complete the pre-test. Read the article and reflect on all content as to how it may be applicable to your practice. Complete the post-test/evaluation and claim credit earned. At this time, physicians will have earned up to 1.0 AMA PRA Category 1 Credit TM. Minimum passing score on the post-test is 70%. Overall Purpose Participants will be able to demonstrate increased knowledge of the clinical treatment of allergy/asthma/immunology and how new information can be applied to their own practices.

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Autoimmune progesterone dermatitis: Case report with history of urticaria, petechiae and palpable pinpoint purpura triggered by medical abortion

Cited by 11 publications

References 26 publications

Catamenial dermatoses associated with autoimmune, inflammatory, and systemic diseases: A systematic review,,

Catamenial dermatoses associated with autoimmune, inflammatory, and systemic diseases: A systematic review,,

Progesterone hypersensitivity: Case report with favorable evolution

Cyclical hypersensitivity, anaphylaxis, and related hormonal reaction

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