2019
DOI: 10.1016/j.anai.2018.11.016
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Cyclical hypersensitivity, anaphylaxis, and related hormonal reaction

Abstract: Although endogenous or exogenous exposure to progesterone or estrogen that induce a spectrum of hypersensitivity reactions and/or other skin eruptions are believed to be uncommon, their prevalence is currently unknown. Clinical manifestations are heterogeneous but typically involve cyclical manifestation of a spectrum of dermatitis conditions and/or systemic symptoms. Diagnosis is made primarily by history in conjunction with in vitro assays to measure specific IgE and provocation challenge testing when approp… Show more

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Cited by 13 publications
(12 citation statements)
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References 70 publications
(118 reference statements)
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“…One hundred twelve articles were found to include a case report meeting our inclusion criteria 3–114 . Within these articles, 132 unique cases of AIPD were identified.…”
Section: Resultsmentioning
confidence: 99%
“…One hundred twelve articles were found to include a case report meeting our inclusion criteria 3–114 . Within these articles, 132 unique cases of AIPD were identified.…”
Section: Resultsmentioning
confidence: 99%
“…Based on current clinical data, progesterone patch is not effective and is not routinely performed. Alternatively, intramuscular injection of progesterone using a concentration of 12.5 to 25 mg of progesterone can be used as an alternative diagnostic test ( 55 ). Both intramuscular or oral progesterone can induce the disease.…”
Section: Discussionmentioning
confidence: 99%
“…Both intramuscular or oral progesterone can induce the disease. However, it is not carried out much in clinical practice due to pain at the intramuscular injection site and poor patient cooperation ( 34 , 55 ). In vitro tests are also increasingly important for detecting APD, such as the leukocyte histamine test (LHR) to assess histamine release from basophils and the interferon-gamma release test to assess progesterone-related T-cell-mediated activity, as well as the enzyme-linked immunosorbent assay (ELISA) to assess progesterone-specific IgE (sIgE), as mentioned earlier ( 34 , 35 , 56 , 57 ).…”
Section: Discussionmentioning
confidence: 99%
“…Esse resultado apresentou como causa mais comum os BNM que são responsáveis por 69.2% das reações alérgicas, seguidos pelo látex com 12.1% e os antibióticos com 8% dos valores totais, esses tipos de reações de hipersensibilidade mediada por IgE (Misbah & Krishna, 2019). Com prevalência de incidência anual no gênero feminino (Lavery & Bernstein, 2019).…”
Section: Discussão Epidemiologia E Principais Causas De Anafilaxiaunclassified
“…Assim, distribui-se os casos anafiláticos assumindo as respectivas porcentagens de incidência: bloqueadores neuromusculares como agentes em 50 a 70%, látex em 12% a 16%, antibióticos ficando com 15%, hipnóticos com 3,0% e opioides com 1,3% (Haque & Nossaman, 2012). Já em questão de prevalência o quadro de anafilaxia tem maior reiteração no sexo feminino aproximadamente 3:1 se comparado com o sexo masculino, tendo uma ligação direta com os hormônios sexuais (Lavery & Bernstein, 2019).…”
Section: Introductionunclassified