Autoimmune Progesterone Dermatitis

Shelley, Walter B.; Preucel, Robert W.; Spoont, Stanley S.

doi:10.1001/jama.1964.03070140041004

Cited by 105 publications

(79 citation statements)

References 5 publications

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“…Other possible causes such as herpesvirus infection or drug reaction can be ruled out. The clinical lesions arc similar to those described in several cases of autoreactivity to P [1][2][3][4][5]. Regrettably, in the only pre viously described case of autoreactivity to 17-OHP [6], the skin lesions were not described in detail.…”

Section: Discussionsupporting

confidence: 67%

“…Autoreactivity against endogenous progesterone (P) has been etiologically associated with several dermatoses [1][2][3][4][5], occurring after the ovulatory phase and remitting spontaneously, during the catamenial period or appearing during pregnancy. Only 1 case of autorcactivity against 17a-hydroxyprogesterone (17-OHP) has been described [6], This case was associated with a serum-binding factor to 17-OHP.…”

Section: Introductionmentioning

confidence: 99%

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Erythema multiforme Associated with Autoreactivity to 17α-Hydroxyprogesterone

Js¹,

Sobrinho²,

Mb³

et al. 1990

Dermatology

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We report a case of a 23-year-old woman who was afflicted with disseminated skin erythema multiforme-like eruptions that started at the menarche, relapsed at the premenstrual periods, dramatically spread during two pregnancies and cleared after abortion; the skin lesions responded dramatically to thalidomide treatment. A high-affinity binding factor to 17α-hydroxyprogesterone (17-OHP) was found in the serum of this patient. Her lymphocytes did not proliferate in vitro after exposure to exogenous 17-OHP but showed significant chromatin activation. There was a decreased expression of HLA antigens at the surface of the patient’s blood lymphocytes. This is a unique well-documented case of erythema multiforme most possibly due to autoreactivity to 17-OHP; the precise mechanism(s) of this autoreactivity has not been established.

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Erythema multiforme Associated with Autoreactivity to 17α-Hydroxyprogesterone

Js¹,

Sobrinho²,

Mb³

et al. 1990

Dermatology

View full text Add to dashboard Cite

show abstract

“…The question of endocrine sensitivity has been in study for some time [6][7][8]. In 1964, Shelley el ai [1] reported a progesterone dermatitis in a woman which was induced by both endogenous and exogenous progesterone and was alleviated by suppression of ovulation. A single oral dose of norethindrone caused, in this case, degranulation of the patient's cir culating basophils.…”

Section: Discussionmentioning

confidence: 99%

“…The premenstrual flares of certain maladies are firmly rooted in patients' and physicians' experience [1], This is well demonstrated by the course of various skin diseases such as acne, psoriasis, lichen ruber planus, atopic der matitis, lupus erythematosus and others [2], Despite an abundance of clinical examples, very little is known about the actual role of hormones in the cau sation of these fluctuations.…”

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confidence: 99%

Hormonal Factors in Dermatitis herpetiformis

Haim¹,

Friedman‐Birnbaum²

1972

Dermatology

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“…En los casos con sintomatología severa o refractaria, se debe considerar la histerectomía con ooferectomía bilateral, la cual constituye el tratamiento definitivo (28) .…”

Section: Tratamientounclassified

Tema 7-2014: Dermatitis Autoinmune, Urticaria Ciclica/Angioedema Y Anafilaxis Por Progesterona

Salas

Velásquez²

2014

RC_UCR-HSJD

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RESUMENLas reacciones cíclicas por progesterona son entidades clínicas muy poco comunes que describen aquellos episodios recurrentes o cíclicos de reacciones alérgicas multisistémicas, que ocurren alrededor de la menstruación y que al parecer, están relacionadas o son exacerbadas durante la fase lútea del ciclo menstrual. Hay poca información al respecto y se encuentran muy pocos reportes de casos que describan dichas reacciones (1,2) . Su diagnóstico es de exclusión y representa un reto considerable desde el punto de vista clínico y del manejo. Los puntos clave para su diagnóstico incluyen la aparición de los síntomas en la fase premenstrual, la desaparición de los mismos con la inhibición de la ovulación y una prueba cutánea positiva a la inyección intradérmica de progesterona. El pilar del tratamiento lo constituye la inhibición de la secreción endógena de progesterona, mediante la supresión de la ovulación con manejo médico, aunque en casos de pacientes con sintomatología severa y refractaria, puede ser necesaria la ooferectomía bilateral. La presente revisión tiene como objetivo actualizar los conocimientos que existen sobre las diferentes presentaciones de las reacciones de hipersensibilidad por progesterona, para poder brindar un diagnóstico certero y un tratamiento adecuado PALABRAS CLAVEDermatitis autoinmune. Progesterona. Angioedema cíclico. Anafilaxis catamenial. Urticaria cíclica. ABSTRACTCyclic progesterone reactions are rare clinical entities that describe recurring or cyclic episodes of multisystemic allergic reactions that occur around menses, and apparently are related or are exacerbated during the lutheal phase of the menstrual cycle. There is little information when

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Autoimmune Progesterone Dermatitis

Cited by 105 publications

References 5 publications

Erythema multiforme Associated with Autoreactivity to 17α-Hydroxyprogesterone

Erythema multiforme Associated with Autoreactivity to 17α-Hydroxyprogesterone

Hormonal Factors in Dermatitis herpetiformis

Tema 7-2014: Dermatitis Autoinmune, Urticaria Ciclica/Angioedema Y Anafilaxis Por Progesterona

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