Autoimmune Hypopituitarism in Patients with Coeliac Disease: Symptoms Confusingly Similar

Collin, Pekka; Hakanen, M; Salmi, Jorma; Mäki, Markku; Kaukinen, Katri

doi:10.1080/003655201750153511

Cited by 26 publications

(9 citation statements)

References 11 publications

(12 reference statements)

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“…The prevalence of rheumatoid arthritis is not increased in celiac disease [44]. Sjogren's syndrome [45], primary hyperparathyroidism [46], hypoparathyroidism [47], hypopituitarism [48] and systemic lupus erythematosus [49,50] have all been described in association with celiac disease, but usually in a small series or case reports.…”

Section: Other Autoimmune Diseasesmentioning

confidence: 95%

Risk of morbidity in contemporary celiac disease

Lewis

Holmes

2010

Expert Review of Gastroenterology & Hepatology

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Celiac disease is one of the most common chronic diseases encountered in the Western world with a serological prevalence of approximately 1%. Since it is so common, much comorbidity will occur either as associations or simply by chance, or as complications of the disorder. Many of the published studies purporting to establish the frequency of these occurrences have been limited by factors such as the source and number of patients considered, choice of control groups and ascertainment bias. Recent epidemiological studies have attempted to minimize these sources of error and provide more reliable information. Autoimmune diseases constitute clinically important associations, of which Type 1 diabetes mellitus and thyroid disorders are the most important. Several liver disorders, including primary biliary cirrhosis and primary sclerosing cholangitis, are also associated. The frequency of malignant complications of celiac disease is much lower than earlier studies have indicated, with lymphoma increased by approximately fivefold and the absolute number of tumors is small. The increase in fracture risk in celiac disease is only modest. Although neurological and psychiatric conditions affect celiac patients, no disorder specifically associated with celiac disease has been identified. Reproductive problems have been overexaggerated. It is important that these co-morbidities are recognized because if not, symptoms will be falsely attributed to deliberate or inadvertent ingestion of gluten, rather than prompt a search for a second diagnosis. Furthermore, in a patient with an established diagnosis that is considered falsely to account for the whole clinical picture, celiac disease is likely to remain undetected.

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Section: Other Autoimmune Diseasesmentioning

confidence: 95%

Risk of morbidity in contemporary celiac disease

Lewis

Holmes

2010

Expert Review of Gastroenterology & Hepatology

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“…Recently, it has been supposed that, in three CD patients poorly responding to a GFD, an autoimmune involvement of the pituitary gland could coexist [10]; moreover, antipituitary antibodies (APA) have been detected in adults and in children with idiopathic growth hormone deficiency (GHD), indicating an autoimmune hypophysitis in these patients [16,18].…”

Section: Introductionmentioning

confidence: 99%

Growth hormone impaired secretion and antipituitary antibodies in patients with coeliac disease and poor catch-up growth after a long gluten-free diet period: a causal association?

et al. 2006

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“…Recently, a study on this issue has been carried out in CD patients [25]. Three CD patients (one female, two males) were reported to be suffering from hypopituitarism, but some of their symptoms were initially considered indicators of a poorly controlled gluten-free diet, causing a delay in treatment.…”

Section: Hypothesesmentioning

confidence: 99%

Mechanisms of Abnormal Puberty in Coeliac Disease

Bona

Marinello

Oderda³

2002

Horm Res Paediatr

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Coeliac disease (CD) is one of the most frequent chronic diseases in childhood. The clinical spectrum has changed; in addition to the classical gastrointestinal form, other clinical manifestations have been described, such as hypogonadism and the consequent delay in onset of puberty. Recent studies reported not only a significantly retarded menarche in untreated CD girls as compared with girls following a gluten-free diet, but also in treated CD a negative effect on pregnancy, resulting in lower birth weight and shorter duration of pregnancy. In boys, there is a reduced serum level of dihydrotestosterone and an increased serum level of luteinizing hormone, an abnormality pattern suggesting androgen resistance. The pathogenesis of CD-related reproductive disorders is still unclear. Some hypotheses may be tried; for example, in CD there is a high level of autoantibodies directed against self-antigens, so there could be antibodies directed against hormones or organs critical for pubertal development. Moreover, in CD there could be a selective malabsorption of micronutrients essential for the metabolism of carrier or receptor proteins for sex hormones.

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Autoimmune Hypopituitarism in Patients with Coeliac Disease: Symptoms Confusingly Similar

Cited by 26 publications

References 11 publications

Risk of morbidity in contemporary celiac disease

Risk of morbidity in contemporary celiac disease

Growth hormone impaired secretion and antipituitary antibodies in patients with coeliac disease and poor catch-up growth after a long gluten-free diet period: a causal association?

Mechanisms of Abnormal Puberty in Coeliac Disease

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