Autoimmune Hemolytic Anemia Presenting in Sézary Syndrome

Abstract

A 52-year-old man, who presented with Sézary syndrome with autoimmune hemolytic anemia (AIHA) and was successfully treated with corticosteroids is reported. Helper function assay determining immunoglobulin confirmed inducer capability of this clonal population. This patient brings to 4 the number of cases of T cell cutaneous lymphoma and AIHA now reported in the English literature, and is the first case of Sézary syndrome and AIHA thus far.

Fatal Microangiopathic Hemolytic Anemia Due to Sézary Syndrome

“…While the bone marrow biopsy did reveal advanced disease, the patient had an elevated reticulocyte count, demonstrating capacity for bone marrow production. Autoimmune hemolytic anemia was also a consideration and has been previously reported in patients with SS [ 8 ]. In this case, the patient’s DAT was negative.…”

Autoimmune Hemolytic Anemia and Cutaneous T Cell Lymphoma Review of the Literature

“…We read with great interest the case reported by Evers et al [1] as we have recently reported a 47-year-old white woman with the diagnosis of cu taneous T cell lymphoma (T4, N3, M0, Bu), who suffered a hemolytic crisis (hemoglobin 3.5 g/dl) due to a widespccificity IgG autoantibody of sus pected anti-D specificity [2]. We thor oughly reviewed the literature, and although Padavic-Knox et al [3] stated that there were two previous reports of autoimmune hemolytic anemia and cutaneous T cell lym phoma, referring to White et al [4] and Lawrence et al [5], they did not realize he was the same patient.…”

“…We thor oughly reviewed the literature, and although Padavic-Knox et al [3] stated that there were two previous reports of autoimmune hemolytic anemia and cutaneous T cell lym phoma, referring to White et al [4] and Lawrence et al [5], they did not realize he was the same patient. Ap parently, Evers et al [1] were unaware of this fact as well. For this reason, the case reported by us [1] constitutes the third case of autoimmune hemolytic anemia in a patient with cutaneous T cell lymphoma.…”

“…Ap parently, Evers et al [1] were unaware of this fact as well. For this reason, the case reported by us [1] constitutes the third case of autoimmune hemolytic anemia in a patient with cutaneous T cell lymphoma.…”