Autoimmune Disease: The Consequence of Deficient T‐Cell Function?*

Abstract

The age-related decrease in T-lymphocyte function is discussed in relation to the onset of autoimmune disease. It is postulated that the decrease in T-cell "immune surveillance" permits: a) the ingress of viruses whose enzymes modify host glycoproteins and render them immunogenic, and b) the replication of viruses incorporated into the genome of cells during infections in early life. The existence of immunodeficiencies too subtle to be detected by our present laboratory methods is postulated and discussed in relation to diseases observed in geriatric patients. It would seem that the prevention of some geriatric diseases should begin in the pediatrician's office.

Reference Values for Blood Findings in Relatively Fit Elderly Persons

“…The large numbers of high results were observed in the determination of immunoglobulins M and A and alpha-1 antitrypsin. Age-related and sex-related changes in immune mechanisms have received great attention (27)(28)(29)(30)(31), but much more basic and clinical research is needed to understand the sig-nificance of these findings.…”

The Biology of Aging: 1976, An Overview†

“…Furthermore, most but not all humans acquire more autoantibodies with age, and in vitro work has not necessarily supported the autoimmune theory. Kay (20) has modified the theory to state that the immune system is a rate‐limiting but not controlling factor in aging. She has postulated that an age‐related decrease in T‐cell (thymus‐controlled) but not B‐cell (bursal) immune surveillance allows the ingress of viruses whose enzymes modify host glycoproteins, rendering them immunogenic and permitting the replication of viruses incorporated into the genome of cells during infections early in life.…”