Autoimmune disease and vaccination: impact on infectious disease prevention and a look at future applications

McKinnon, John; Maksimowicz-McKinnon, Kathleen

doi:10.1016/j.trsl.2015.08.008

Cited by 21 publications

(18 citation statements)

References 139 publications

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“…In some of these cases, autoimmunity is suspected to result from molecular mimicry in which antigens of the pathogen resemble host epitopes (31)(32)(33). Thus, avoiding potentially detrimental cross-reactive responses is a high priority when developing new vaccines (32)(33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

Immunizations with Enterotoxigenic Escherichia coli Heat-Stable Toxin Conjugates Engender Toxin-Neutralizing Antibodies in Mice That Also Cross-React with Guanylin and Uroguanylin

et al. 2019

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Infection with enterotoxigenic Escherichia coli (ETEC) is a common cause of childhood diarrhea in low-and middle-income countries, as well as of diarrhea among travelers to these countries. In children, ETEC strains secreting the heatstable toxin (ST) are the most pathogenic, and there are ongoing efforts to develop vaccines that target ST. One important challenge for ST vaccine development is to construct immunogens that do not elicit antibodies that cross-react with guanylin and uroguanylin, which are endogenous peptides involved in regulating the activity of the guanylate cyclase-C (GC-C) receptor. We immunized mice with both human ST (STh) and porcine ST (STp) chemically coupled to bovine serum albumin, and the resulting sera neutralized the toxic activities of both STh and STp. This suggests that a vaccine based on either ST variant can confer cross-protection. However, several anti-STh and anti-STp sera cross-reacted with the endogenous peptides, suggesting that the ST sequence must be altered to reduce the risk of unwanted crossreactivity. Epitope mapping of four monoclonal anti-STh and six anti-STp antibodies, all of which neutralized both STh and STp, revealed that most epitopes appear to have at least one amino acid residue shared with guanylin or uroguanylin. Despite this, only one monoclonal antibody displayed demonstrable cross-reactivity to the endogenous peptides, suggesting that targeted mutations of a limited number of ST residues may be sufficient to obtain a safe ST-based vaccine.

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Section: Discussionmentioning

confidence: 99%

Immunizations with Enterotoxigenic Escherichia coli Heat-Stable Toxin Conjugates Engender Toxin-Neutralizing Antibodies in Mice That Also Cross-React with Guanylin and Uroguanylin

et al. 2019

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“…determined that infections in the early childhood may protect from autoimmune diseases [24]. However, in his newest article, McKinnon et al [18] states that vaccinations could nowadays not only prevent from infections, but also function as potential immunologic therapy for patients with autoimmune diseases [25].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, it's worth mentioning that according to the work of Scicchitano et al [25] nutraceuticals (functional food) can lower the risk of metabolic problems, such as atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Changes in Diet and Lifestyle may Lower the Risk of Type 1 Diabetes Mellitus in Children-Environmental Factors Influencing Type 1 Diabetes Mellitus Morbidity

Korzeniowska¹,

Derkowska²,

Żalińska³

et al. 2016

J Diabetes Metab

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Introduction: A significant increase in the incidence of type 1 diabetes has been observed. Environmental factors are considered to play a major role in aetiology of type 1 diabetes. Material and methods:The study included 153 patients aged 0-18 years old: 75 admitted to Department of Paediatrics, Diabetology and Endocrinology due to newly diagnosed type 1 diabetes (DM1) and 78 admitted to the Paediatric Hospital "Polanki" in the years 2010-2015. The parents were asked to fill in a questionnaire about environmental factors and development of their children. Statistical analyses were performed using STATISTICA 12 package, using T-student test, Chi-square test (with Yates modification) and U Mann-Whitney test. respectively). Moreover, a significant reduction of DM1 risk was observed in children vaccinated with combined vaccines and recommended vaccinations against Streptococcus pneumoniae and rotaviruses (59% to 26,6%, p=0.001; 60% to 25,3%, p<0.001). No difference was found between the groups concerning: body weight in the second year of life, length of breast feeding, gluten introduction, viral infections, source of drinking water or way of heating. Conclusions:Finding environmental factors that cause increase of incidence of type 1 diabetes is relevant for the further studies and prevention of this illness. Limiting highly processed food and sweet beverages consumption, reducing 'screen time' as well as combined vaccinations may have an important influence on lowering DM1 risk. Results:Children from the Study Group ate significantly more candies, chocolate bars and drank more sweet beverages prior to the diagnosis of DM1 (72% to 55%, p=0.03; 80% to 42%, p<0.0006; 60% to 40%, p=0.01 respectively). Children with DM1 spent more time in front of TV set (53% to 36%, p=0.06; 2,26 hours to 1,8 hours, p=0.02.

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“…Since infectious diseases, including vaccinepreventable diseases, are among the most common triggers, and possibly inducers, of autoimmune disorders, it is plausible to expect a net protective effect of vaccination (65). On the other hand, there is currently a widespread concern that in predisposed persons vaccination may entail a risk of triggering an autoimmune disorder, as well as exacerbating the course of an existing disorder (66).…”

Section: Vaccination In Patients With Autoimmune Disordersmentioning

confidence: 99%

Vaccination and Autoimmune Phenomena

Janković

2017

CEJP

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Autoimmune disease and vaccination: impact on infectious disease prevention and a look at future applications

Cited by 21 publications

References 139 publications

Immunizations with Enterotoxigenic Escherichia coli Heat-Stable Toxin Conjugates Engender Toxin-Neutralizing Antibodies in Mice That Also Cross-React with Guanylin and Uroguanylin

Immunizations with Enterotoxigenic Escherichia coli Heat-Stable Toxin Conjugates Engender Toxin-Neutralizing Antibodies in Mice That Also Cross-React with Guanylin and Uroguanylin

Changes in Diet and Lifestyle may Lower the Risk of Type 1 Diabetes Mellitus in Children-Environmental Factors Influencing Type 1 Diabetes Mellitus Morbidity

Vaccination and Autoimmune Phenomena

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